The social network of microorganisms—how auxotrophies shape complex communities

K Zengler, LS Zaramela - Nature Reviews Microbiology, 2018 - nature.com
Microorganisms engage in complex interactions with other organisms and their
environment. Recent studies have shown that these interactions are not limited to the …

Nanoparticle-mediated cancer cell therapy: Basic science to clinical applications

J Verma, C Warsame, RK Seenivasagam… - Cancer and Metastasis …, 2023 - Springer
Every sixth person in the world dies due to cancer, making it the second leading severe
cause of death after cardiovascular diseases. According to WHO, cancer claimed nearly 10 …

The role of the microbiome in exacerbations of chronic lung diseases

RP Dickson, FJ Martinez, GB Huffnagle - The Lancet, 2014 - thelancet.com
Culture-independent microbiological techniques have shown a previously unappreciated
complexity to the bacterial microbiome of the respiratory tract that forces reconsideration of …

Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis

RP Dickson, JR Erb-Downward… - The lancet Respiratory …, 2014 - thelancet.com
Pneumonia is a major cause of morbidity and mortality for which no new methods of
treatment have entered clinical practice since the discovery of antibiotics. Innovations in the …

Modelling approaches for studying the microbiome

M Kumar, B Ji, K Zengler, J Nielsen - Nature microbiology, 2019 - nature.com
Advances in metagenome sequencing of the human microbiome have provided a plethora
of new insights and revealed a close association of this complex ecosystem with a range of …

Multiscale agent-based and hybrid modeling of the tumor immune microenvironment

KA Norton, C Gong, S Jamalian, AS Popel - Processes, 2019 - mdpi.com
Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

Simulating cancer growth with multiscale agent-based modeling

Z Wang, JD Butner, R Kerketta, V Cristini… - Seminars in cancer …, 2015 - Elsevier
There have been many techniques developed in recent years to in silico model a variety of
cancer behaviors. Agent-based modeling is a specific discrete-based hybrid modeling …

INFEKTA—An agent-based model for transmission of infectious diseases: The COVID-19 case in Bogotá, Colombia

J Gomez, J Prieto, E Leon, A Rodríguez - PloS one, 2021 - journals.plos.org
The transmission dynamics of the coronavirus—COVID-19—have challenged humankind at
almost every level. Currently, research groups around the globe are trying to figure out such …

Synergistic integration between machine learning and agent-based modeling: A multidisciplinary review

W Zhang, A Valencia, NB Chang - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
Agent-based modeling (ABM) involves developing models in which agents make adaptive
decisions in a changing environment. Machine-learning (ML) based inference models can …

In silico modelling of cancer nanomedicine, across scales and transport barriers

NR Stillman, M Kovacevic, I Balaz… - NPJ Computational …, 2020 - nature.com
Nanoparticles promise to improve the treatment of cancer through their increasingly
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …