The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …

The emergence of hypervirulence (hv) and carbapenem resistance (CR) as distinct
evolutionary directions for Klebsiella pneumoniae presents a significant threat in clinical …

Colistin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses health
challenges. To investigate the prevalence and molecular characteristics of colistin-resistant …

Polymyxins are last-line antibiotics employed against multidrug-resistant (MDR) Klebsiella
pneumoniae. Worryingly, polymyxin resistance is rapidly on the rise globally. Polymyxins …

In recent years, polymyxin has been used as a last-resort therapy for carbapenem-resistant
bacterial infections. The emergence of heteroresistance (HR) to polymyxin hampers the …

Background: The rate of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection has
been increasing rapidly worldwide and, poses a significant risk to human health. Effective …

Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-
resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in …

The emergence of polymyxin B (PB) resistant Gram-negative bacteria poses an important
clinical and public health threat. Antibiotic adjuvants development is a complementary …

In this study, we aimed to identify potential metabolic biomarkers that can improve the
diagnostic accuracy of sepsis. Sixty-six patients including 30 septic and 36 nonsepsis …

Background The use of antibiotic adjuvants is a complementary strategy to the development
of new antibiotics. The essential role of the ArnA dehydrogenase domain (ArnA_DH) in the …