Immunology of pediatric HIV infection

NH Tobin, GM Aldrovandi - Immunological reviews, 2013 - Wiley Online Library
Most infants born to human immunodeficiency virus (HIV)‐infected women escape HIV
infection. Infants evade infection despite an immature immune system and, in the case of …

Effectiveness of community mobilisation models in improving HIV testing services uptake among women and children in Nigeria: A quasi-experimental study

O Arije, R Titus, A Olaniran, A Dadi, D Garba… - Global Public …, 2023 - Taylor & Francis
Nigeria carries a high burden of HIV infections, with Taraba State having a prevalence of
2.49%. This quasi-experimental study evaluated the impact of the Lafiyan Yara project …

High mortality in HIV-infected children diagnosed in hospital underscores need for faster diagnostic turnaround time in prevention of mother-to-child transmission of …

A Wagner, J Slyker, A Langat, I Inwani, J Adhiambo… - BMC pediatrics, 2015 - Springer
Background Despite expanded programs for prevention of mother-to-child HIV transmission
(PMTCT), HIV-infected infants may not be diagnosed until they are ill. Comparing HIV …

Urgent versus post-stabilisation antiretroviral treatment in hospitalised HIV-infected children in Kenya (PUSH): a randomised controlled trial

IN Njuguna, LM Cranmer, VO Otieno, C Mugo… - The lancet HIV, 2018 - thelancet.com
Background Urgent antiretroviral therapy (ART) among hospitalised HIV-infected children
might accelerate recovery or worsen outcomes associated with immune reconstitution. We …

Implementation and operational research: active referral of children of HIV-positive adults reveals high prevalence of undiagnosed HIV

AD Wagner, C Mugo, IN Njuguna… - JAIDS Journal of …, 2016 - journals.lww.com
Objectives: Few routine systems exist to test older, asymptomatic children for HIV. Testing all
children in the population has high uptake but is inefficient, whereas testing only …

The impact of structured mentor mother programs on presentation for early infant diagnosis testing in rural North-Central Nigeria: a prospective paired cohort study

NA Sam-Agudu, HO Ramadhani, C Isah… - JAIDS Journal of …, 2017 - journals.lww.com
Background: Early infant diagnosis (EID) by 2 months of age is an important prevention of
mother-to-child cascade step that serves as an early postpartum indicator of program …

Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South …

KG Technau, E Kalk, A Coovadia, V Black… - JAIDS Journal of …, 2014 - journals.lww.com
Background: By 2011, South African prevention of mother-to-child transmission (PMTCT) of
HIV programs had reduced perinatal HIV transmission at 6 weeks of age to 2.7%. We …

Higher HIV-1 Env gp120-specific antibody-dependent cellular cytotoxicity (ADCC) activity is associated with lower levels of defective HIV-1 provirus

R Yucha, ML Litchford, CS Fish, ZA Yaffe… - Viruses, 2023 - mdpi.com
A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …

Using health provider insights to inform pediatric HIV disclosure: a qualitative study and practice framework from Kenya

K Beima-Sofie, G John-Stewart, B Shah… - AIDS patient care and …, 2014 - liebertpub.com
Optimal pediatric HIV disclosure impacts illness and developmental experiences while
improving access to timely treatment. However, disclosure rates in high HIV prevalence …

Compartmentalized cytomegalovirus replication and transmission in the setting of maternal HIV-1 infection

J Slyker, C Farquhar, C Atkinson… - Clinical infectious …, 2014 - academic.oup.com
Background. Cytomegalovirus (CMV) infection is associated with adverse outcomes in
human immunodeficiency virus (HIV)–exposed infants. Determinants of vertical CMV …