Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV)
infection which is often limited to a febrile illness, but may lead to very aggressive …

Lipid droplets are the intracellular sites for neutral lipid storage. They are critical for lipid
metabolism and energy homeostasis, and their dysfunction has been linked to many …

Positive-sense single-stranded RNA (+ ssRNA) viruses comprise many (re-) emerging
human pathogens that pose a public health problem. Our innate immune system and, in …

Viral infections continue to represent major challenges to public health, and an enhanced
mechanistic understanding of the processes that contribute to viral life cycles is necessary …

Chikungunya virus (CHIKV) is the aetiological agent of the mosquito-borne disease
chikungunya fever, a debilitating arthritic disease that, during the past 7 years, has caused …

Most cells respond to viral infections by activating innate immune pathways that lead to the
induction of antiviral restriction factors. One such factor, viperin, was discovered almost two …

Highlights•Individual ISGs have measurable phenotypes in vivo.•ISGs control viral
pathogenesis through a variety of mechanisms.•ISG effects in vivo are often virus-specific …

Viral infection of the cell is able to initiate a signaling cascade of events that ultimately
attempts to limit viral replication and prevent escalating infection through expression of host …

Blood CD14+ monocytes are frontline immunomodulators categorized into classical,
intermediate or non-classical subsets, and subsequently differentiated into M1 pro-or M2 …

Chikungunya virus (CHIKV) has infected millions of people in the tropical and subtropical
regions since its reemergence in the last decade. We recently identified the nontoxic plant …