NF-κB and its role in checkpoint control

AC Betzler, MN Theodoraki, PJ Schuler… - International Journal of …, 2020 - mdpi.com
Nuclear factor-κB (NF-κB) has been described as one of the most important molecules
linking inflammation to cancer. More recently, it has become clear that NF-κB is also …

Targeting the NF-κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy

N Ebrahimi, AHRR Abdulwahid, A Mansouri… - Cellular and Molecular …, 2024 - Springer
Advances in cancer immunotherapy over the last decade have led to the development of
several agents that affect immune checkpoints. Inhibitory receptors expressed on T cells that …

Analysis of genomic and transcriptomic variations as prognostic signature for lung adenocarcinoma

T Zengin, T Önal-Süzek - BMC bioinformatics, 2020 - Springer
Background Lung cancer is the leading cause of the largest number of deaths worldwide
and lung adenocarcinoma is the most common form of lung cancer. In order to understand …

[HTML][HTML] Chronic inhalation of H2S in low concentration induces immunotoxicity and inflammatory effects in lung tissue of rats

K Li, J Wang, L Fang, Y Lou, J Li, Q Li, Q Luo… - Ecotoxicology and …, 2024 - Elsevier
Hydrogen sulfide (H 2 S) is a typical odour compound mainly causing respiratory and central
nervous system symptoms. However, the immunotoxicity of inhaled H 2 S and the underlying …

Expression of intracellular components of the NF-κB alternative pathway (NF-κB2, RelB, NIK and Bcl3) is associated with clinical outcome of NSCLC patients

FID Dimitrakopoulos, AG Antonacopoulou… - Scientific reports, 2019 - nature.com
A growing number of studies has shed light on the role of the NF-κΒ in non-small-cell lung
cancer (NSCLC). To address the significance of major effectors of the NF-κΒ alternative …

Multifaceted roles for BCL3 in cancer: a proto-oncogene comes of age

G Seaton, H Smith, A Brancale, AD Westwell… - Molecular Cancer, 2024 - Springer
In the early 1990'sa group of unrelated genes were identified from the sites of recurring
translocations in B-cell lymphomas. Despite sharing the nomenclature 'Bcl', and an …

[HTML][HTML] A four-gene signature predicts survival in clear-cell renal-cell carcinoma

J Dai, Y Lu, J Wang, L Yang, Y Han, Y Wang, D Yan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Clear-cell renal-cell carcinoma (ccRCC) is the most common pathological subtype of renal
cell carcinoma (RCC), accounting for about 80% of RCC. In order to find potential prognostic …

Strain-specific behavior of Mycobacterium tuberculosis in A549 lung cancer cell line

S Hadifar, S Mostafaei, A Behrouzi, A Fateh, P Riahi… - BMC …, 2021 - Springer
Background A growing body of evidence has shown the association between tuberculosis
(TB) infection and lung cancer. However, the possible effect of strain‐specific behavior of …

Expression of immune system-related membrane receptors CD40, RANK, BAFFR and LTβR is associated with clinical outcome of operated non-small-cell lung cancer …

FID Dimitrakopoulos, AE Kottorou… - Journal of clinical …, 2019 - mdpi.com
An increasing number of studies implicates the NF-κB (Nuclear Factor of kappa light chain
gene enhancer in B cells) alternative pathway in non-small-cell lung cancer (NSCLC). We …

Ferroptosis-Related APOE, BCL3 and ALOX5AP Gene Polymorphisms are Associated with the Risk of Thyroid Cancer

Z Xiao, H Zhao - Pharmacogenomics and Personalized Medicine, 2022 - Taylor & Francis
Purpose This study aimed to evaluate the association between polymorphisms in the
ferroptosis-related genes apolipoprotein E (APOE), BCL3 transcription coactivator (BCL3) …