[HTML][HTML] History of ALS and the competing theories on pathogenesis: IFCN handbook chapter
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder of
the human motor system, first described in the 19th Century. The etiology of ALS appears to …
the human motor system, first described in the 19th Century. The etiology of ALS appears to …
The glymphatic system and Amyotrophic lateral sclerosis
The glymphatic system and the meningeal lymphatic vessels provide a pathway for transport
of solutes and clearance of toxic material from the brain. Of specific relevance to ALS, this is …
of solutes and clearance of toxic material from the brain. Of specific relevance to ALS, this is …
Transcranial static magnetic stimulation for amyotrophic lateral sclerosis: a bicentric, randomised, double-blind placebo-controlled phase 2 trial
V Di Lazzaro, F Ranieri, A Doretti… - The Lancet Regional …, 2024 - thelancet.com
Background Enhanced glutamatergic transmission leading to motor neuron death is
considered the major pathophysiological mechanism of amyotrophic lateral sclerosis (ALS) …
considered the major pathophysiological mechanism of amyotrophic lateral sclerosis (ALS) …
Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice
Abstract Objective Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to
provide neuroprotection in a range of neurodegenerative diseases. In the fatal motor neuron …
provide neuroprotection in a range of neurodegenerative diseases. In the fatal motor neuron …
Size-based effects of anthropogenic ultrafine particles on lysosomal TRPML1 channel and autophagy in motoneuron-like cells
S Sapienza, V Tedeschi, B Apicella, F Palestra… - International Journal of …, 2022 - mdpi.com
Background: An emerging body of evidence indicates an association between
anthropogenic particulate matter (PM) and neurodegeneration. Although the historical focus …
anthropogenic particulate matter (PM) and neurodegeneration. Although the historical focus …
Als patient-derived motor neuron networks exhibit microscale dysfunction and mesoscale compensation rendering them highly vulnerable to perturbation
V Fiskum, N Winter-Hjelm, N Christiansen, A Sandvig… - Biorxiv, 2024 - biorxiv.org
Amyotrophic lateral sclerosis affects upper and lower motor neurons, causing progressive
neuropathology leading to structural and functional alterations of affected neural networks …
neuropathology leading to structural and functional alterations of affected neural networks …
How do we get from hyperexcitability to excitotoxicity in amyotrophic lateral sclerosis?
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease that, at present,
has no effective cure. Evidence of increased circulating glutamate and hyperexcitability of …
has no effective cure. Evidence of increased circulating glutamate and hyperexcitability of …
Nanoplastics and Neurodegeneration in ALS
Plastic production, which exceeds one million tons per year, is of global concern. The
constituent low-density polymers enable spread over large distances and micro/nano …
constituent low-density polymers enable spread over large distances and micro/nano …
[PDF][PDF] Probing neuronal (dys) function in motor cortex of ALS transgenic mice by in vivo two-photon calcium imaging
WYV Kan - 2023 - edoc.ub.uni-muenchen.de
Probing neuronal (dys)function in motor cortex of ALS transgenic mice by in vivo two-photon
calcium imaging Page 1 Probing neuronal (dys)function in motor cortex of ALS transgenic …
calcium imaging Page 1 Probing neuronal (dys)function in motor cortex of ALS transgenic …
[引用][C] Hyperexcitability, neurodegeneration, and disease progression in amyotrophic lateral sclerosis
MC Kiernan, SB Park - Muscle & Nerve, 2023 - Wiley Online Library
See article on pages 149–156 in this issue.