Development, initial validation, and application of a visual read method for [18F]MK‐6240 tau PET
JL Shuping, DC Matthews, K Adamczuk… - … Research & Clinical …, 2023 - Wiley Online Library
Background The positron emission tomography (PET) radiotracer [18F] MK‐6240 exhibits
high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD) …
high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD) …
[HTML][HTML] Cross-sectional and longitudinal comparison of tau imaging with 18F-MK6240 and 18F-flortaucipir in populations matched for age, MMSE and brain beta …
Objectives Longitudinal tau quantification may provide a useful marker of drug efficacy in
clinical trials. Different tau PET tracers may have different sensitivity to longitudinal changes …
clinical trials. Different tau PET tracers may have different sensitivity to longitudinal changes …
One-Year Longitudinal Changes in Tau Accumulation on [18F] PI-2620 PET in the Alzheimer Spectrum
We investigated the longitudinal changes in cortical tau accumulation and their association
with cognitive decline in patients in the Alzheimer disease (AD) continuum using 2-(2-([18F] …
with cognitive decline in patients in the Alzheimer disease (AD) continuum using 2-(2-([18F] …
Tau Imaging in Late Traumatic Brain Injury: A [18F]MK-6240 Positron Emission Tomography Study
G Vanderlinden, L Michiels, M Koole… - Journal of …, 2024 - liebertpub.com
Epidemiological studies have identified prior traumatic brain injury (TBI) as a risk factor for
developing Alzheimer's disease (AD). Neurofibrillary tangles (NFTs) are common to AD and …
developing Alzheimer's disease (AD). Neurofibrillary tangles (NFTs) are common to AD and …
Tau PET burden in Brodmann areas 35 and 36 is associated with individual differences in cognition in non-demented older adults
Introduction The accumulation of neurofibrillary tau tangles, a neuropathological hallmark of
Alzheimer's disease (AD), occurs in medial temporal lobe (MTL) regions early in the disease …
Alzheimer's disease (AD), occurs in medial temporal lobe (MTL) regions early in the disease …
Test–retest performance of [18F]MK-6240 tau burden and relative delivery indices in cognitively normal older subjects using PET/MRI
Accurate interpretation of quantitative positron emission tomography (PET) outcomes hinges
on understanding the test–retest variability (T-RT). Previous studies of the tau-PET ligand …
on understanding the test–retest variability (T-RT). Previous studies of the tau-PET ligand …
Evaluating the effect of extra-cerebral off-target binding in [F-18] MK6240 PET scans in early-stage Alzheimer's disease
A McVea, A DiFilippo, MJ McLachlan… - Imaging …, 2024 - direct.mit.edu
Abstract [F-18] MK6240 is a Positron Emission Tomography (PET) radioligand with favorable
imaging characteristics for measuring tau aggregation in Alzheimer's disease (AD). In this …
imaging characteristics for measuring tau aggregation in Alzheimer's disease (AD). In this …
[PDF][PDF] Tau positron emission tomography in tauopathies: A narrative review
H Lee, Y Gu, SW Seo, SH Moon - Precision and Future Medicine, 2023 - pfmjournal.org
Aggregation of misfolded tau in the brain is a major pathological feature common in various
neurodegenerative disorders known as tauopathies, including Alzheimer's disease …
neurodegenerative disorders known as tauopathies, including Alzheimer's disease …