DAMPs and NETs in sepsis

NL Denning, M Aziz, SD Gurien, P Wang - Frontiers in immunology, 2019 - frontiersin.org
Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to
infection. Much has been focused on host response to pathogens mediated through the …

Methods for the assessment of NET formation: from neutrophil biology to translational research

M Stoimenou, G Tzoros, P Skendros… - International journal of …, 2022 - mdpi.com
Several studies have indicated that a neutrophil extracellular trap (NET) formation, apart
from its role in host defense, can contribute to or drive pathogenesis in a wide range of …

Epitope editing enables targeted immunotherapy of acute myeloid leukaemia

G Casirati, A Cosentino, A Mucci, M Salah Mahmoud… - Nature, 2023 - nature.com
Despite the considerable efficacy observed when targeting a dispensable lineage antigen,
such as CD19 in B cell acute lymphoblastic leukaemia,, the broader applicability of adoptive …

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

AJ Monteith, JM Miller, CN Maxwell, WJ Chazin… - Science …, 2021 - science.org
Neutrophils and macrophages are critical to the innate immune response, but cooperative
mechanisms used by these cells to combat extracellular pathogens are not well understood …

[HTML][HTML] IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F+ neutrophils

L Borkner, LM Curham, MM Wilk, B Moran… - Mucosal …, 2021 - Elsevier
Understanding the mechanism of protective immunity in the nasal mucosae is central to the
design of more effective vaccines that prevent nasal infection and transmission of Bordetella …

Cognitive dysfunction in systemic lupus erythematosus: immunopathology, clinical manifestations, neuroimaging and management

D Seet, NA Allameen, SH Tay, J Cho, A Mak - Rheumatology and Therapy, 2021 - Springer
Cognitive dysfunction (CD) is a common yet often clinically subtle manifestation that
considerably impacts the health-related quality of life in patients with systemic lupus …

A secreted sirtuin from Campylobacter jejuni contributes to neutrophil activation and intestinal inflammation during infection

SM Callahan, TJ Hancock, RS Doster, CB Parker… - Science …, 2023 - science.org
Histone modifications control numerous processes in eukaryotes, including inflammation.
Some bacterial pathogens alter the activity or expression of host-derived factors, including …

The emerging role of neutrophil extracellular traps in fungal infection

C Liang, N Lian, M Li - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Fungal infections are global public health problems and can lead to substantial human
morbidity and mortality. Current antifungal therapy is not satisfactory, especially for invasive …

The perspectives of NETosis on the progression of obesity and obesity-related diseases: mechanisms and applications

J Li, L Yin, S Chen, Z Li, J Ding, J Wu… - Frontiers in Cell and …, 2023 - frontiersin.org
Obesity is a disease commonly associated with urbanization and can also be characterized
as a systemic, chronic metabolic condition resulting from an imbalance between energy …

Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers

G Guzmán-Martínez, C Marañón… - Frontiers in …, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) patients display an increased risk of cardiovascular
disease (CVD). With the improved clinical management of other classical severe …