Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

The mitotic spindle is a bipolar cellular structure, built from tubulin polymers, called
microtubules, and interacting proteins. This macromolecular machine orchestrates …

Within the mitotic spindle, kinesin motors cross-link and slide overlapping microtubules.
Some of these motors exhibit off-axis power strokes, but their impact on motility and force …

Cellular cargoes, including lipid droplets and mitochondria, are transported along
microtubules using molecular motors such as kinesins. Many experimental and …

Antiparallel microtubule bundles are essential structural elements of many cytoskeletal
structures, for instance, the mitotic spindle. Sliding of microtubules relative to each other can …

Introduction Myosin II has been investigated with optical trapping, but single motor-filament
assay arrangements are not reflective of the complex cellular environment. To understand …

In addition to their force-generating motor domains, kinesin motor proteins feature various
accessory domains enabling them to fulfill a variety of functions in the cell. Human kinesin-3 …

During cell division, cross-linking motors determine the architecture of the spindle, a
dynamic microtubule network that segregates the chromosomes in eukaryotes. It is unclear …

Kinesin is a motor protein that plays important roles in a variety of cellular functions. In vivo,
multiple kinesin molecules are bound to cargo and work as a team to produce larger forces …

Kinesins and microtubule associated proteins (MAPs) are critical to sustain life, facilitating
cargo transport, cell division, and motility. To interrogate the mechanistic underpinnings of …