Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …

Lactate was recently found to mediate histone lysine lactylation and facilitate polarization of
M1 macrophages, indicating its role in metabolic regulation of gene expression. During …

The Zinc finger and SCAN domain containing 4 (ZSCAN4) protein, expressed transiently in
pluripotent stem cells, gametes, and early embryos, extends telomeres, enhances genome …

The process of induced pluripotent stem cells (iPSCs) reprogramming involves several
crucial events, including the mesenchymal-epithelial transition (MET), activation of …

Background Abundantly expressed factors in the oocyte cytoplasm can remarkably
reprogram terminally differentiated germ cells or somatic cells into totipotent state within a …

The epigenetic memory stored in the dynamic modifications, such as base modifications of
cytosine (C) in DNA, including methylation/hydroxymethylation/demethylation, causes …

The biology of preimplantation embryo gene expression began 56 years ago with studies of
the effects of protein synthesis inhibition and discovery of changes in embryo metabolism …

Decabromodiphenyl ethane (DBDPE) is a novel retardant. DBDPE is used in various
flammable consumer products such as electronics, building materials, textiles, and children's …

Chemical compounds have recently been introduced as alternative and non‐integrating
inducers of pluripotent stem cell fate. However, chemical reprogramming is hampered by …