PET imaging of neuroinflammation in Alzheimer's disease

R Zhou, B Ji, Y Kong, L Qin, W Ren, Y Guan… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

In vivo Imaging of Glial Activation in Alzheimer's Disease

P Edison, CK Donat, M Sastre - Frontiers in neurology, 2018 - frontiersin.org
Alzheimer's disease (AD) is characterized by memory loss and decline of cognitive function,
associated with progressive neurodegeneration. While neuropathological processes like …

Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue

E Georges, C Sottas, Y Li… - The journal of …, 2021 - academic.oup.com
The translocator protein (TSPO) is a five-helix transmembrane protein localized to the outer
mitochondria membrane. Radioligand binding assays and chemical crosslinking showed …

MicroPET evidence for a hypersensitive neuroinflammatory profile of gp120 mouse model of HIV

JW Young, CV Barback, LA Stolz, SM Groman… - Psychiatry Research …, 2022 - Elsevier
Despite increased survivability for people living with HIV (PLWH), HIV-related cognitive
deficits persist. Determining biological mechanism (s) underlying abnormalities is critical to …

Evaluating the role of microglial cells in clearance of Aβ from Alzheimer's brain

AL Manchikalapudi, RR Chilakala, K Kalia… - ACS Chemical …, 2019 - ACS Publications
Ever increasing incidence of Alzheimer's diseases (AD) has been reported all over the
globe, and practically no drug is currently available for its treatment. In the past 15 years, not …

A Systematic Review on Dementia and Translocator Protein (TSPO): When Nuclear Medicine Highlights an Underlying Expression

M Conte, MS De Feo, F Corica, J Gorica, MMA Sidrak… - Biomolecules, 2023 - mdpi.com
Background: Translocator protein (TSPO) is a neuroinflammation hallmark. Different TSPO
affinity compounds have been produced and over time, the techniques of radiolabeling have …

Development of a Multimodal MRI Study to Characterize Morpho-Functional Features in Rodent Models of Alzheimer's Disease

D Tolomeo - 2019 - oro.open.ac.uk
Alzheimer's Disease (AD) is the most common form of dementia, recognized by the World
Health Organization as a global public health priority. It is a complex pathology …

[图书][B] Beyond Amyloid and Tau: A Role for Neural Injury and Gliosis in the Pathogenesis of Alzheimer's Disease

AP Merluzzi - 2018 - search.proquest.com
Alzheimer's disease (AD) is characterized by amyloid plaques (Aβ), neurofibrillary tau
tangles (NFT), and memory impairments leading to dementia. Yet post-mortem evidence …