Pluripotent stem-cell lines can be obtained through the reprogramming of somatic cells from
different tissues and species by ectopic expression of defined factors. In theory, these cells …

Induced pluripotent stem cells (iPSCs) are a new type of pluripotent cells that can be
obtained by reprogramming animal and human differentiated cells. In this review, issues …

Summary The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's
disease (PD). To better understand the link between mutant LRRK2 and PD pathology, we …

A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for
study. One solution is to derive induced pluripotent stem cells from patients and differentiate …

In contrast to CRISPR/Cas9 nucleases, CRISPR base editors (BE) and prime editors (PE)
enable predefined nucleotide exchanges in genomic sequences without generating DNA …

Human fibroblasts can be induced into pluripotent stem cells (iPSCs), but the
reprogramming efficiency is quite low. Here, we screened a panel of candidate factors in the …

Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by gene transfer of
reprogramming transcription factors. Expression levels of these factors strongly influence the …

Induced pluripotent stem (iPS) cells can be obtained by the introduction of defined factors
into somatic cells. The combination of Oct4 (also known as Pou5f1), Sox2 and Klf4 (which …

Human-induced pluripotent stem cells (hiPSCs) are generated from somatic cells by ectopic
expression of the 4 reprogramming factors (RFs) Oct-4, Sox2, Klf4, and c-Myc. To better …

Immune rejection is an important obstacle to the use of allogeneic 'off-the-shelf'cells for
transplantation into immunocompetent patients. Genetic modification has emerged as a …