Improving vaccine performance with adjuvants

FR Vogel - Clinical Infectious Diseases, 2000 - academic.oup.com
New vaccines are presently under development and in testing for the control of infectious
diseases, including human immunodeficiency virus (HIV) and tuberculosis. Several of these …

Respiratory syncytial virus vaccines

RA Dudas, RA Karron - Clinical microbiology reviews, 1998 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is the most important cause of viral lower respiratory tract
illness (LRI) in infants and children worldwide and causes significant LRI in the elderly and …

Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease

MF Delgado, S Coviello, AC Monsalvo, GA Melendi… - Nature medicine, 2009 - nature.com
Respiratory syncytial virus (RSV) is a leading cause of hospitalization in infants. A formalin-
inactivated RSV vaccine was used to immunize children and elicited nonprotective …

Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant

HL Davis, J Schorr, AM Krieg - US Patent 6,406,705, 2002 - Google Patents
The present invention relates generally to adjuvants, and in particular to methods and
products utilizing a synergistic combination of immunostimulatory oligonucleotides having at …

The role of IFN in respiratory syncytial virus pathogenesis

JE Durbin, TR Johnson, RK Durbin… - The Journal of …, 2002 - journals.aai.org
Formalin-inactivated respiratory syncytial virus (RSV) vaccine preparations have been
shown to cause enhanced disease in naive hosts following natural infection. In this study we …

NK T Cells Contribute to Expansion of CD8+ T Cells and Amplification of Antiviral Immune Responses to Respiratory Syncytial Virus

TR Johnson, S Hong, L Van Kaer, Y Koezuka… - Journal of …, 2002 - Am Soc Microbiol
ABSTRACT CD1d-deficient mice have normal numbers of T lymphocytes and natural killer
cells but lack Vα14+ natural killer T cells. Respiratory syncytial virus (RSV) …

[PDF][PDF] Eosinophil response against classical and emerging respiratory viruses: COVID-19

JM Rodrigo-Muñoz, B Sastre, JA Cañas… - J Investig Allergol Clin …, 2021 - jiaci.org
Eosinophil Response Against Classical and Emerging Respiratory Viruses: COVID-19 Short
running title: Eosinophils and respirator Page 1 1 J Investig Allergol Clin Immunol 2021; Vol …

Understanding the mechanisms of viral induced asthma: new therapeutic directions

NG Hansbro, JC Horvat, PA Wark… - Pharmacology & …, 2008 - Elsevier
Asthma is a common and debilitating disease that has substantially increased in prevalence
in Western Societies in the last 2 decades. Respiratory tract infections by respiratory …

Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration

JR Baldridge, Y Yorgensen, JR Ward, JT Ulrich - Vaccine, 2000 - Elsevier
The induction of protective immunity stemming from vaccines delivered by mucosal routes is
dependent on the development of safe and effective mucosal adjuvants. The …

Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector

L Martinez-Sobrido, N Gitiban… - Journal of …, 2006 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract disease
in infants and the elderly, but no safe and effective RSV vaccine is yet available. For reasons …