Obesity in type 1 diabetes: pathophysiology, clinical impact, and mechanisms

KD Corbin, KA Driscoll, RE Pratley, SR Smith… - Endocrine …, 2018 - academic.oup.com
There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

Highlighting the role of obesity and insulin resistance in type 1 diabetes and its associated cardiometabolic complications

G Karamanakos, A Kokkinos, M Dalamaga… - Current obesity reports, 2022 - Springer
Abstract Purpose of Review This narrative review appraises research data on the potentially
harmful effect of obesity and insulin resistance (IR) co-existence with type 1 diabetes …

[HTML][HTML] The profiling and role of miRNAs in diabetes mellitus

M Kim, X Zhang - Journal of diabetes and clinical research, 2019 - ncbi.nlm.nih.gov
Diabetes mellitus (DM), a complex metabolic disease, has become a global threat to human
health worldwide. Over the past decades, an enormous amount of effort has been devoted to …

MicroRNAs and diabetic kidney disease: Systematic review and bioinformatic analysis

TS Assmann, M Recamonde-Mendoza… - Molecular and cellular …, 2018 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Emerging
evidence has suggested a role for miRNAs in the development of diabetic kidney disease …

Circulating miRNA expression in long-standing type 1 diabetes mellitus

P Morales-Sánchez, C Lambert, J Ares-Blanco… - Scientific reports, 2023 - nature.com
Type 1 diabetes is a chronic autoimmune disease which results in inefficient regulation of
glucose homeostasis and can lead to different vascular comorbidities through life. In this …

MicroRNA: a new generation therapeutic target in diabetic nephropathy

S Dewanjee, N Bhattacharjee - Biochemical pharmacology, 2018 - Elsevier
Diabetic nephropathy (DN) is one of the most prevalent lethal complications of diabetes that
leads to end stage renal disease. Although several clinical approaches exist to attenuate …

Serum biomarkers for diagnosis and prediction of type 1 diabetes

L Yi, AC Swensen, WJ Qian - Translational Research, 2018 - Elsevier
Type 1 diabetes (T1D) culminates in the autoimmune destruction of the pancreatic βcells,
leading to insufficient production of insulin and development of hyperglycemia. Serum …

Cardiovascular disease-associated microRNAs as novel biomarkers of first-trimester screening for gestational diabetes mellitus in the absence of other pregnancy …

I Hromadnikova, K Kotlabova, L Krofta - International Journal of Molecular …, 2022 - mdpi.com
We assessed the diagnostic potential of cardiovascular disease-associated microRNAs for
the early prediction of gestational diabetes mellitus (GDM) in singleton pregnancies of …

Natural killer cells as key mediators in type I diabetes immunopathology

G Gardner, CA Fraker - Frontiers in immunology, 2021 - frontiersin.org
The immunopathology of type I diabetes (T1D) presents a complicated case in part because
of the multifactorial origin of this disease. Typically, T1D is thought to occur as a result of …

Diabetes mellitus and cardiovascular risk assessment in mothers with a history of gestational diabetes mellitus based on postpartal expression profile of micrornas …

I Hromadnikova, K Kotlabova, L Dvorakova… - International journal of …, 2020 - mdpi.com
Mothers with a history of gestational diabetes mellitus (GDM) have an increased risk of
developing diabetes in the future and a lifelong cardiovascular risk. Postpartal expression …