Functions of sphingolipids in pathogenesis during host–pathogen interactions

J Wang, YL Chen, YK Li, DK Chen, JF He… - Frontiers in …, 2021 - frontiersin.org
Sphingolipids are a class of membrane lipids that serve as vital structural and signaling
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …

The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Fungal sphingolipids: role in the regulation of virulence and potential as targets for future antifungal therapies

C Mota Fernandes, M Del Poeta - Expert review of anti-infective …, 2020 - Taylor & Francis
Introduction The antifungal therapy currently available includes three major classes of drugs:
polyenes, azoles and echinocandins. However, the clinical use of these compounds faces …

Cytosolic pH controls fungal MAPK signaling and pathogenicity

TR Fernandes, M Mariscal, A Serrano, D Segorbe… - Mbio, 2023 - Am Soc Microbiol
Mitogen-activated protein kinases (MAPKs) regulate a variety of cellular processes in
eukaryotes. In fungal pathogens, conserved MAPK pathways control key virulence functions …

Stress-activated protein kinases in human fungal pathogens

AM Day, J Quinn - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
The ability of fungal pathogens to survive hostile environments within the host depends on
rapid and robust stress responses. Stress-activated protein kinase (SAPK) pathways are …

The dynamics and role of sphingolipids in eukaryotic organisms upon thermal adaptation

JHTM Fabri, NP de Sá, I Malavazi, M Del Poeta - Progress in lipid research, 2020 - Elsevier
All living beings have an optimal temperature for growth and survival. With the advancement
of global warming, the search for understanding adaptive processes to climate changes has …

Aspergillus fumigatus Hsp90 interacts with the main components of the cell wall integrity pathway and cooperates in heat shock and cell wall stress adaptation

MC Rocha, K Minari, JHTM Fabri… - Cellular …, 2021 - Wiley Online Library
The initiation of Aspergillus fumigatus infection occurs via dormant conidia deposition into
the airways. Therefore, conidial germination and subsequent hyphal extension and growth …

[HTML][HTML] Phylogenomics and gene selection in Aspergillus welwitschiae: Possible implications in the pathogenicity in Agave sisalana

G Quintanilha-Peixoto, MP Marone, FT Raya, J José… - Genomics, 2022 - Elsevier
Aspergillus welwitschiae causes bole rot disease in sisal (Agave sisalana and related
species) which affects the production of natural fibers in Brazil, the main worldwide producer …

SakA Regulates Morphological Development, Ochratoxin A Biosynthesis and Pathogenicity of Aspergillus westerdijkiae and the Response to Different Environmental …

P Si, G Wang, W Wu, S Hussain, L Guo, W Wu, Q Yang… - Toxins, 2023 - mdpi.com
Ochratoxin A (OTA), as a common mycotoxin, has seriously harmful effects on agricultural
products, livestock and humans. There are reports on the regulation of SakA in the MAPK …

Deciphering the crosstalk mechanisms of wheat-stem rust Pathosystem: Genome-scale prediction unravels novel host targets

R Kataria, R Kaundal - Frontiers in Plant Science, 2022 - frontiersin.org
Triticum aestivum (wheat), a major staple food grain, is affected by various biotic stresses.
Among these, fungal diseases cause about 15–20% of yield loss, worldwide. In this study …