Novel agents and drug targets to meet the challenges of resistant fungi

MW McCarthy, DP Kontoyiannis… - The Journal of …, 2017 - academic.oup.com
The emergence of drug-resistant fungi poses a major threat to human health. Despite
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …

Fruiting-body development in ascomycetes

S Pöggeler, M Nowrousian, I Teichert, A Beier… - Physiology and Genetics …, 2018 - Springer
Fruiting bodies are multicellular structures that are developed during the sexual life cycle of
filamentous ascomycetes and protect the products of meiosis. In this review, we will provide …

Genome-wide exonic small interference RNA-mediated gene silencing regulates sexual reproduction in the homothallic fungus Fusarium graminearum

H Son, AR Park, JY Lim, C Shin, YW Lee - PLoS genetics, 2017 - journals.plos.org
Various ascomycete fungi possess sex-specific molecular mechanisms, such as repeat-
induced point mutations, meiotic silencing by unpaired DNA, and unusual adenosine-to …

[HTML][HTML] Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial …

Y Lu, Y Sun, C Drummer IV, GK Nanayakkara, Y Shao… - Redox biology, 2019 - Elsevier
To test our hypothesis that proatherogenic lysophosphatidylcholine (LPC) upregulates
trained immunity pathways (TIPs) in human aortic endothelial cells (HAECs), we conducted …

Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum

SA Cobbold, AM Vaughan, IA Lewis, HJ Painter… - Journal of Biological …, 2013 - ASBMB
The malaria parasite Plasmodium falciparum depends on glucose to meet its energy
requirements during blood-stage development. Although glycolysis is one of the best …

Hyperlipidemia may synergize with hypomethylation in establishing trained immunity and promoting inflammation in NASH and NAFLD

CIV Drummer, F Saaoud, Y Sun, D Atar… - Journal of …, 2021 - Wiley Online Library
We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH)
microarray data and microarray/RNA‐seq data from various mouse models of nonalcoholic …

Proteomic insights of chitosan mediated inhibition of Fusarium oxysporum f. sp. cucumerinum

E Elagamey, MAE Abdellatef, MY Arafat - Journal of Proteomics, 2022 - Elsevier
Fusarium oxysporum f. sp. cucumerinum (FOC) infects cucumber plants, causing significant
yield losses. Chitosan is a natural biodegradable compound that has antifungal properties …

AbaA Regulates Conidiogenesis in the Ascomycete Fungus Fusarium graminearum

H Son, MG Kim, K Min, YS Seo, JY Lim, GJ Choi… - PLoS one, 2013 - journals.plos.org
Fusarium graminearum (teleomorph Gibberella zeae) is a prominent pathogen that infects
major cereal crops such as wheat, barley, and maize. Both sexual (ascospores) and asexual …

Differential contribution of RNA interference components in response to distinct Fusarium graminearum virus infections

J Yu, KM Lee, WK Cho, JY Park, KH Kim - Journal of virology, 2018 - Am Soc Microbiol
The mechanisms of RNA interference (RNAi) as a defense response against viruses remain
unclear in many plant-pathogenic fungi. In this study, we used reverse genetics and virus …

Functional Roles of FgLaeA in Controlling Secondary Metabolism, Sexual Development, and Virulence in Fusarium graminearum

HK Kim, S Lee, SM Jo, SP McCormick, RAE Butchko… - PLoS …, 2013 - journals.plos.org
Fusarium graminearum, the causal agent of Fusarium head blight in cereal crops, produces
mycotoxins such as trichothecenes and zearalenone in infected plants. Here, we focused on …