Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance

CJ Kim, R Romero, P Chaemsaithong… - American journal of …, 2015 - Elsevier
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at
different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and …

Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome

M Tchirikov, N Schlabritz-Loutsevitch… - Journal of perinatal …, 2018 - degruyter.com
Mid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal
membranes prior to 28 weeks of gestation, complicates approximately 0.4%–0.7% of all …

Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics

KR Theis, R Romero, AD Winters, JM Greenberg… - American journal of …, 2019 - Elsevier
Background The human placenta has been traditionally viewed as sterile, and microbial
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …

[HTML][HTML] Evidence that intra-amniotic infections are often the result of an ascending invasion–a molecular microbiological study

R Romero, N Gomez-Lopez, AD Winters… - Journal of perinatal …, 2019 - degruyter.com
Background Microbial invasion of the amniotic cavity resulting in intra-amniotic infection is
associated with obstetrical complications such as preterm labor with intact or ruptured …

Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes

BH Yoon, R Romero, JY Park, KJ Oh, JH Lee… - American journal of …, 2019 - Elsevier
Background Intra-amniotic infection is present in 10% of patients with an episode of preterm
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …

Spontaneous preterm birth: advances toward the discovery of genetic predisposition

JF Strauss III, R Romero, N Gomez-Lopez… - American journal of …, 2018 - Elsevier
Evidence from family and twin-based studies provide strong support for a significant
contribution of maternal and fetal genetics to the timing of parturition and spontaneous …

The human Ureaplasma species as causative agents of chorioamnionitis

EL Sweeney, SJ Dando, SG Kallapur… - Clinical microbiology …, 2017 - Am Soc Microbiol
The human Ureaplasma species are the most frequently isolated microorganisms from the
amniotic fluid and placentae of women who deliver preterm and are also associated with …

Evidence of perturbations of the cytokine network in preterm labor

R Romero, JC Grivel, AL Tarca… - American journal of …, 2015 - Elsevier
Objective Intraamniotic inflammation/infection is the only mechanism of disease with
persuasive evidence of causality for spontaneous preterm labor/delivery. Previous studies …

Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes

M Kacerovsky, R Romero, M Stepan, J Stranik… - American journal of …, 2020 - Elsevier
Background Preterm prelabor rupture of the membranes (PPROM) is frequently complicated
by intraamniotic inflammatory processes such as intraamniotic infection and sterile …

Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin?

N Gomez-Lopez, R Romero, Y Xu, Y Leng… - American journal of …, 2017 - Elsevier
Background Neutrophils are the most abundant white blood cells found in the amniotic
cavity of women with intraamniotic infection and/or inflammation. The current belief is that …