Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density
diminishing, and degeneration of bone microstructure, which is accompanied by a tendency …

SOX9 is a pivotal transcription factor in chondrocytes, a lineage essential in skeletogenesis.
Its mandatory role in transactivating many cartilage-specific genes is well established …

Decades of work have identified the signaling pathways that regulate the differentiation of
chondrocytes during bone formation, from their initial induction from mesenchymal …

ABSTRACT SOX9 is a pivotal transcription factor in developing and adult cartilage. Its gene
is expressed from the multipotent skeletal progenitor stage and is active throughout …

The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint
movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood …

Much of the mammalian skeleton is composed of bones that originate from cartilage
templates through endochondral ossification. Elucidating the mechanisms that control …

OBJECTIVE: To review the literature on the role and regulation of chondrocyte terminal
differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a …