Drug repurposing for spinal cord injury: progress towards therapeutic intervention for primary factors and secondary complications

L Guha, H Kumar - Pharmaceutical Medicine, 2023 - Springer
Spinal cord injury (SCI) encompasses a plethora of complex mechanisms like the
involvement of major cell death pathways, neurodegeneration of spinal cord neurons …

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies

V Das, JH Miller, CG Alladi, N Annadurai… - Medicinal Research …, 2024 - Wiley Online Library
As the world population ages, there will be an increasing need for effective therapies for
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …

[HTML][HTML] Antiviral Drug Discovery

Z Zhou, X Liu, D Kang - International Journal of Molecular Sciences, 2024 - mdpi.com
A vast and painful price has been paid in the battle against viruses in global health. The
COVID-19 pandemic is a stark reminder of the urgent need for antiviral agents, which …

Repurposing of FDA approved kinase inhibitor bosutinib for mitigation of radiation induced damage via inhibition of JNK pathway

B Singh, RS Patwardhan, D Pal, DK Maurya… - Toxicology and Applied …, 2024 - Elsevier
Radiotherapy is a common modality for cancer treatment. However, it is often associated
with normal tissue toxicity in 20–80% of the patients. Radioprotectors can improve the …

[HTML][HTML] A novel computational drug repurposing approach for Systemic Lupus Erythematosus (SLE) treatment using Semantic Web technologies

A Noor, A Assiri - Saudi Journal of Biological Sciences, 2021 - Elsevier
2. Materials and methods This study proposes an integrative drug repurposing framework
using SW technologies to precisely enable the discovery of the hidden mechanisms …

Phytochemicals in Drug Discovery-A Confluence of Tradition and Innovation

P Chihomvu, A Ganesan, S Gibbons, M Johannson… - 2024 - preprints.org
Phytochemicals have a long and successful history in drug discovery. With recent
advancements in analytical techniques and methodologies, discovering bioactive leads from …

Drug repurposing for regenerative medicine and cosmetics: Scientific, technological and economic issues.

TD Vu, DT Luong, TT Ho, N Thi, V Singh… - Progress in Molecular …, 2024 - europepmc.org
Regenerative medicine and cosmetics are currently two outstanding fields for drug
discovery. Although many pharmaceutical products for regenerative medicine and cosmetics …

[图书][B] Computational and Chemical Approaches to Drug Repurposing

X Li - 2023 - search.proquest.com
Drug repurposing, which entails discovering novel therapeutic applications for already
existing drugs, provides numerous benefits compared to conventional drug discovery …

[PDF][PDF] Kidney on a Chip Development and Drug Efficacy Testing for Renal Hypoxic Reperfusion Injury

CSA Rahim - 2023 - oak.jejunu.ac.kr
The microphysiological system (MPS), dynamic complex cell culture technology has the
ability to mimic the human pathophysiological system. The main goal of MPS is to recreate …