Lynch syndrome, molecular mechanisms and variant classification
Patients with the heritable cancer disease, Lynch syndrome, carry germline variants in the
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …
[HTML][HTML] Vaccines for immunoprevention of DNA mismatch repair deficient cancers
A Hernandez-Sanchez, M Grossman… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
The development of cancer vaccines to induce tumor-antigen specific immune responses
was sparked by the identification of antigens specific to or overexpressed in cancer cells …
was sparked by the identification of antigens specific to or overexpressed in cancer cells …
[HTML][HTML] Lynch syndrome genetics and clinical implications
P Peltomäki, M Nyström, JP Mecklin, TT Seppälä - Gastroenterology, 2023 - Elsevier
Lynch syndrome (LS) is one of the most prevalent hereditary cancer syndromes in humans
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …
and accounts for some 3% of unselected patients with colorectal or endometrial cancer and …
Immunotherapy: recent advances and its future as a neoadjuvant, adjuvant, and primary treatment in colorectal cancer
I Yu, A Dakwar, K Takabe - Cells, 2023 - mdpi.com
Immunotherapy in colorectal cancer (CRC) has made great strides within the past decade.
Immune checkpoint inhibitors are a class of immunotherapy and have been shown to greatly …
Immune checkpoint inhibitors are a class of immunotherapy and have been shown to greatly …
Lynch syndrome cancer vaccines: A roadmap for the development of precision immunoprevention strategies
Hereditary cancer syndromes (HCS) account for 5~ 10% of all cancer diagnosis. Lynch
syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA …
syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA …
Advances in vaccine development for cancer prevention and treatment in Lynch Syndrome
Lynch Syndrome (LS) is one of the most common hereditary cancer syndromes, and is
caused by mutations in one of the four DNA mismatch repair (MMR) genes, namely MLH1 …
caused by mutations in one of the four DNA mismatch repair (MMR) genes, namely MLH1 …
[HTML][HTML] Hereditary cancer variants and homologous recombination deficiency in biliary tract cancer
Y Okawa, Y Iwasaki, TA Johnson, N Ebata, C Inai… - Journal of …, 2023 - Elsevier
Background & Aims The heritability and actionability of variants in homologous
recombination-related genes in biliary tract cancers (BTCs) are uncertain. Although …
recombination-related genes in biliary tract cancers (BTCs) are uncertain. Although …
[HTML][HTML] A highly sensitive pan-cancer test for microsatellite instability
Microsatellite instability (MSI) is an evolving biomarker for cancer detection and treatment.
MSI was first used to identify patients with Lynch syndrome, a hereditary form of colorectal …
MSI was first used to identify patients with Lynch syndrome, a hereditary form of colorectal …
[HTML][HTML] Deep learning can predict bevacizumab therapeutic effect and microsatellite instability directly from histology in epithelial ovarian cancer
Epithelial ovarian cancer (EOC) remains a significant cause of mortality among gynecologic
cancers, with the majority of cases being diagnosed at an advanced stage. Before targeted …
cancers, with the majority of cases being diagnosed at an advanced stage. Before targeted …
[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gastrointestinal cancer
RJ Kelly, K Bever, J Chao, KK Ciombor… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Gastrointestinal (GI) cancers, including esophageal, gastroesophageal junction, gastric,
duodenal and distal small bowel, biliary tract, pancreatic, colon, rectal, and anal cancer …
duodenal and distal small bowel, biliary tract, pancreatic, colon, rectal, and anal cancer …