Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
D Blum, S Torch, N Lambeng, MF Nissou… - Progress in …, 2001 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …
loss of the dopaminergic neurons of the substantia nigrapars compacta. Although the …
Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway
Human idiopathic Parkinson's disease (PD) is a progressive neurodegenerative disorder
that is primarily characterized by degeneration of the dopaminergic neurons of the …
that is primarily characterized by degeneration of the dopaminergic neurons of the …
Pathology of Parkinson's disease: changes other than the nigrostriatal pathway
KA Jellinger - Molecular and chemical neuropathology, 1991 - Springer
In Parkinson's disease (PD), in addition to degeneration of the nigrostriatal dopaminergic
pathway, a variety of neuronal systems are involved, causing multiple neuromediator …
pathway, a variety of neuronal systems are involved, causing multiple neuromediator …
The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the …
This Commentary compares the connections of the dopaminergic system with the striatum in
rats and primates with respect to two levels of striatal organization: a tripartite functional …
rats and primates with respect to two levels of striatal organization: a tripartite functional …
Differing patterns of striatal 18F‐dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy
DJ Brooks, V Ibanez, GV Sawle, N Quinn… - Annals of Neurology …, 1990 - Wiley Online Library
Using positron emission tomography (PET), we studied regional striatal 18F‐dopa uptake in
16 patients with L‐dopa‐responsive Parkinson's disease (PD), 18 patients with multiple …
16 patients with L‐dopa‐responsive Parkinson's disease (PD), 18 patients with multiple …
[123I] FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease.
J Booij, G Tissingh, GJ Boer, JD Speelman… - Journal of Neurology …, 1997 - jnnp.bmj.com
OBJECTIVES: The main neuropathological feature in Parkinson's disease is a severe
degeneration of the dopaminergic neurons in the substantia nigra resulting in a loss of …
degeneration of the dopaminergic neurons in the substantia nigra resulting in a loss of …
Correlation of apomorphine-and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats
JL Hudson, CG van Horne, I Strömberg, S Brock… - Brain research, 1993 - Elsevier
Abstract In the unilateral 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's
disease, controversy exists concerning the use of apomorphine-or d-amphetamine-induced …
disease, controversy exists concerning the use of apomorphine-or d-amphetamine-induced …
Parallel basal ganglia circuits for voluntary and automatic behaviour to reach rewards
HF Kim, O Hikosaka - Brain, 2015 - academic.oup.com
The basal ganglia control body movements, value processing and decision-making. Many
studies have shown that the inputs and outputs of each basal ganglia structure are …
studies have shown that the inputs and outputs of each basal ganglia structure are …
The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease
• A group of healthy control subjects and patients with Parkinson's disease were investigated
using positron emission tomography and two tracers as indicators of different specific …
using positron emission tomography and two tracers as indicators of different specific …
[HTML][HTML] Dopamine neurons encoding long-term memory of object value for habitual behavior
Dopamine neurons promote learning by processing recent changes in reward values, such
that reward may be maximized. However, such a flexible signal is not suitable for habitual …
that reward may be maximized. However, such a flexible signal is not suitable for habitual …