The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …

Intranasal administration is a promising route for brain drug delivery. However, it can be
difficult to formulate drugs that have low water solubility into high strength intranasal …

This work aimed to develop and produce lacosamide-loaded niosomes coated with chitosan
(LCA-CTS-NSM) using a thin-film hydration method and the Box-Behnken design. The effect …

Background: Epilepsy is one of the major neurological disorders, affecting about 50 million
people globally. Oral, intravenous and rectal delivery systems are available for the …

This study aimed to examine the impact of different surface properties of poly (lactic-co-
glycolic) acid (PLGA) nanoparticles (P NPs) and PLGA-Poloxamer nanoparticles (PP NPs) …

Objective: The objective of the present research is to formulate solid lipid nanoparticles
(SLN) of CH to improve its oral bioavailability. Methods: Cinnacalcet hydrochloride (CH) …

Objectives: The study aimed to prepare carbamazepine in solid lipid nanoparticle form (CBZ-
SLN) in order to enhance its anticonvulsant effect. Method: Eight formulations of CBZ-SLNs …

Human immunodeficiency virus (HIV), which induces acquired immunodeficiency syndrome
(AIDS), is among the most lethal viral infections worldwide. Although the realm of highly …

Lamotrigine is used for neurological disorders and antiepileptic therapy at frequent dosing
due to its poor solubility. The present work aims to study the influence of combining the …

This study presents the initial attempt at introducing a magnetic molecularly imprinted
polymer (MIP) designed specifically for lamotrigine with the purpose of functioning as a drug …