Unpredicted human safety events in clinical trials for new drugs are costly in terms of human
health and money. The drug discovery industry attempts to minimize those events with …

Background: Damage or destruction of sensory hair cells in the inner ear leads to hearing or
balance deficits that can be debilitating, especially in older adults. Unfortunately, the …

This is a good thing because animals show other organisms how to stay healthy in their
environment. Biologists can learn more about a lot ofdifferent biological processes by …

Exposure to continuous moderate noise levels is known to impair the auditory system
leading to Noise-Induced Hearing Loss (NIHL) in animals including humans. The …

Sensory hair cells are specialized mechanotransductive receptors required for hearing and
vestibular function. Loss of hair cells in humans and other mammals is permanent and …

Zebrafish are increasingly used in auditory studies, in part due to the development of several
transgenic lines that express hair cell-specific fluorescent proteins. However, it is largely …

Overexposure to loud noise is known to lead to deficits in auditory sensitivity and perception.
We studied the effects of noise exposure on sensorimotor behaviors of larval (5–7 days post …

Age-related hearing loss (ARHL) is a debilitating disorder for millions worldwide. While there
are multiple underlying causes of ARHL, one common factor is loss of sensory hair cells. In …

Sensory hair cells are the mechanotransductive receptors that detect gravity, sound, and
vibration in all vertebrates. Damage to these sensitive receptors often results in deficits in …

During development, otic sensory progenitors give rise to hair cells and supporting cells. In
mammalian adults, differentiated and quiescent sensory cells are unable to generate new …