Novel pathways for implantation and establishment and maintenance of pregnancy in mammals

FW Bazer, G Wu, TE Spencer… - MHR: Basic science …, 2009 - academic.oup.com
Uterine receptivity to implantation varies among species, and involves changes in
expression of genes that are coordinate with attachment of trophectoderm to uterine lumenal …

Conceptus elongation in ruminants: roles of progesterone, prostaglandin, interferon tau and cortisol

K Brooks, G Burns, TE Spencer - Journal of animal science and …, 2014 - Springer
The majority of pregnancy loss in ruminants occurs during the first three weeks after
conception, particularly during the period of conceptus elongation that occurs prior to …

Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation

N Forde, ME Beltman, GB Duffy, P Duffy… - Biology of …, 2011 - academic.oup.com
In cattle, elevated concentrations of circulating progesterone (P4) in the immediate
postconception period are associated with advanced conceptus development, while low P4 …

Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?

N Forde, F Carter, TE Spencer, FW Bazer… - Biology of …, 2011 - academic.oup.com
This study sought to determine the earliest response of the bovine uterine endometrium to
the presence of the conceptus at key developmental stages of early pregnancy. There were …

Single-cell transcriptomic characterization of sheep conceptus elongation and implantation

GX Jia, WJ Ma, ZB Wu, S Li, XQ Zhang, Z He, SX Wu… - Cell Reports, 2023 - cell.com
Bidirectional communication between the developing conceptus and endometrium is
essential for pregnancy recognition and establishment in ruminants. We dissect the …

Transcriptomic analysis of the bovine endometrium: what is required to establish uterine receptivity to implantation in cattle?

N Forde, P Lonergan - Journal of Reproduction and Development, 2012 - jstage.jst.go.jp
In cattle, the majority of pregnancy loss can be attributed to early embryonic loss which
occurs prior maternal recognition of pregnancy on Day 16 (Day 0= ovulation). During this …

Proteomic analysis of uterine fluid during the pre-implantation period of pregnancy in cattle

N Forde, PA McGettigan, JP Mehta, L O'Hara… - …, 2014 - rep.bioscientifica.com
Gonadal sex differentiation proceeds by the interplay of various genes including the
transcription factors and secretory factors in a complex network. The sex-differentiating …

Effects of low progesterone on the endometrial transcriptome in cattle

N Forde, JP Mehta, M Minten, MA Crowe… - Biology of …, 2012 - academic.oup.com
The objective of the present study was to determine how low progesterone (P4) affects the
endometrial transcriptome, with specific emphasis on those changes that may impact …

Physiology and Endocrinology Symposium: biological role of interferon tau in endometrial function and conceptus elongation

P Dorniak, FW Bazer, TE Spencer - Journal of animal science, 2013 - academic.oup.com
This review integrates established and new information on the biological role of ovarian
progesterone (P4) and interferon tau as well as conceptus-and endometrial-derived factors …

Comparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2), on gene expression in bovine endometrium

S Bauersachs, SE Ulbrich… - Biology of …, 2012 - academic.oup.com
Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition
signal produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and …