Simple Summary The unfolded protein response (UPR) is the cells' way of maintaining the
balance of protein folding in the endoplasmic reticulum, which is the section of the cell …

Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

The endoplasmic reticulum (ER) is an important site for protein folding and maturation in
eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its …

The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

The endoplasmic reticulum (ER) acts as a moving organelle with many important cellular
functions. As the ER lacks sufficient nutrients under pathological conditions leading to …

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Tumour cells endure both oncogenic and environmental stresses during cancer
progression. Transformed cells must meet increased demands for protein and lipid …

Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is
observed in many physiological and pathological conditions. To cope with endoplasmic …

The endoplasmic reticulum (ER) is an essential organelle in eukaryotic cells for the storage
and regulated release of calcium and as the entrance to the secretory pathway. Protein …

Oxidative stress is caused by an imbalance in cellular redox state due to the accumulation of
reactive oxygen species (ROS). While homeostatic levels of ROS are important for cell …