This paper is intended to give a comprehensive review of light-sheet (LS) microscopy from
an optics perspective. As such, emphasis is placed on the advantages that LS microscope …

Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Mitochondrial functions are heavily influenced by acid–base homeostasis. Hence,
elucidation of the mitochondrial pH is essential in living cells, and its alterations during …

Formation of the body of vertebrate embryos proceeds sequentially by posterior addition of
tissues from the tail bud. Cells of the tail bud and the posterior presomitic mesoderm, which …

Images generated by a microscope are never a perfect representation of the biological
specimen. Microscopes and specimen preparation methods are prone to error and can …

Calcium signals occur in specific spatio‐temporal patterns in response to various stimuli and
are coordinated with, for example, hormonal signals, for physiological and developmental …

Lysosomes are important sites for macromolecular degradation, defined by an acidic
lumenal pH of∼ 4.5. To better understand lysosomal pH, we designed a novel, genetically …

Disorders of lysosomal physiology have increasingly been found to underlie the pathology
of a rapidly growing cast of neurodevelopmental disorders and sporadic diseases of aging …

Many lysosome functions are determined by a lumenal pH of∼ 5.0, including the activity of
resident acid-activated hydrolases. Lysosome pH (pHlys) is often increased in …