Translating the MAM model of psychosis to humans

G Modinos, P Allen, AA Grace, P McGuire - Trends in neurosciences, 2015 - cell.com
Elevated dopamine function and alterations in medial temporal lobe (MTL) structure and
function are two of the most robust findings in schizophrenia, but how interactions between …

A systematic review and meta-analysis of structural and functional brain alterations in individuals with genetic and clinical high-risk for psychosis and bipolar disorder

LP Luna, J Radua, L Fortea, G Sugranyes… - Progress in Neuro …, 2022 - Elsevier
Neuroimaging findings in people at either genetic risk or at clinical high-risk for psychosis
(CHR-P) or bipolar disorder (CHR-B) remain unclear. A meta-analytic review of whole-brain …

Functional neuroimaging abnormalities in youth with psychosis spectrum symptoms

DH Wolf, TD Satterthwaite, ME Calkins… - JAMA …, 2015 - jamanetwork.com
Importance The continuum view of the psychosis spectrum (PS) implies that, in population-
based samples, PS symptoms should be associated with neural abnormalities similar to …

Progressive cortical reorganisation: a framework for investigating structural changes in schizophrenia

L Palaniyappan - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
One of the few well-replicated features of schizophrenia is the demonstration of
neuroanatomical abnormalities affecting cortical and subcortical grey matter (GM). Evidence …

Disrupted salience network functional connectivity and white-matter microstructure in persons at risk for psychosis: findings from the LYRIKS study

C Wang, F Ji, Z Hong, JS Poh, R Krishnan… - Psychological …, 2016 - cambridge.org
BackgroundSalience network (SN) dysconnectivity has been hypothesized to contribute to
schizophrenia. Nevertheless, little is known about the functional and structural …

Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation

P Allen, CA Chaddock, A Egerton… - Schizophrenia …, 2015 - academic.oup.com
Little is known about the neurobiological factors that determine functional outcome in people
at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical …

Repeated Δ9-Tetrahydrocannabinol Exposure in Adolescent Monkeys: Persistent Effects Selective for Spatial Working Memory

CD Verrico, H Gu, ML Peterson… - American Journal of …, 2014 - Am Psychiatric Assoc
Objective Epidemiological findings suggest that, relative to adults, adolescents are more
vulnerable to the adverse persistent effects of cannabis on working memory. However, the …

Lack of evidence for regional brain volume or cortical thickness abnormalities in youths at clinical high risk for psychosis: findings from the longitudinal youth at risk …

P Klauser, J Zhou, JKW Lim, JS Poh… - Schizophrenia …, 2015 - academic.oup.com
There is cumulative evidence that young people in an “at-risk mental state”(ARMS) for
psychosis show structural brain abnormalities in frontolimbic areas, comparable to, but less …

Aberrant temporal connectivity in persons at clinical high risk for psychosis

T Colibazzi, Z Yang, G Horga, CG Yan… - Biological Psychiatry …, 2017 - Elsevier
Background Schizophrenia, a neurodevelopmental disorder, involves abnormalities in
functional connectivity (FC) across distributed neural networks, which are thought to …

Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia

W Pu, Q Luo, L Palaniyappan, Z Xue, S Yao… - Psychological …, 2016 - cambridge.org
BackgroundA large-scale network named the default mode network (DMN) dynamically
cooperates and competes with an external attention system (EAS) to facilitate various …