Recent advances in optical mapping have allowed the construction of improved genome
assemblies with greater contiguity. Optical mapping also enables genome comparison and …

Oncogene amplification, a major driver of cancer pathogenicity, is often mediated through
focal amplification of genomic segments. Recent results implicate extrachromosomal DNA …

Here, we report a new multi‐optical maps scaffolder (MOMS) aiming at utilizing
complementary information among optical maps labelled by distinct enzymes. This pipeline …

Optical mapping is a unique system that is capable of producing high-resolution, high-
throughput genomic map data that gives information about the structure of a genome …

Motivation Optical mapping data is used in many core genomics applications, including
structural variation detection, scaffolding assembled contigs and mis-assembly detection …

Background Optical maps record locations of specific enzyme recognition sites within long
genome fragments. This long-distance information enables aligning genome assembly …

Genome wide optical maps are high resolution restriction maps that give a unique numeric
representation to a genome. They are produced by assembling hundreds of thousands of …

Detecting structural variation (SV) in eukaryotic genomes is of broad interest due to its often
dramatic phenotypic effects, but remains a major, costly challenge based on DNA …

Oncogene amplification, a major driver of cancer pathogenicity, is often mediated through
focal amplification of genomic segments. Recent results implicate extrachromosomal DNA …

A key problem in processing raw optical mapping data (Rmaps) is finding Rmaps originating
from the same genomic region. These sets of related Rmaps can be used to correct errors in …