Targeting the epigenetic regulation of antitumour immunity
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …
cancer onset and progression. Although defective gene regulation often affects oncogenic …
Regulatory T cells in autoimmune disease
M Dominguez-Villar, DA Hafler - Nature immunology, 2018 - nature.com
In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …
considerably. Key observations have challenged the traditional definition of Treg cells and …
Regulatory T cells: regulation of identity and function
T regulatory cells suppress a variety of immune responses to self-antigens and play a role in
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …
peripheral tolerance maintenance by limiting autoimmune disorders, and other pathological …
Regulatory T cells: the many faces of Foxp3
Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a
requisite role in the maintenance of immunological homeostasis and prevention of …
requisite role in the maintenance of immunological homeostasis and prevention of …
Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes
M Ono - Immunology, 2020 - Wiley Online Library
The transcription factor Foxp3 controls the differentiation and function of regulatory T‐cells
(Treg). Studies in the past decades identified numerous Foxp3‐interacting protein partners …
(Treg). Studies in the past decades identified numerous Foxp3‐interacting protein partners …
Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease
W Zhang, X Liu, Y Zhu, X Liu, Y Gu… - European Journal of …, 2021 - Wiley Online Library
Regulatory T (Treg) cells and T helper type 17 (Th17) cells play important roles in adaptive
immune responses, antagonizing each other in immune disorders. Th17/Treg balance is …
immune responses, antagonizing each other in immune disorders. Th17/Treg balance is …
Clinical, immunological, and molecular heterogeneity of 173 patients with the phenotype of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) …
E Gambineri, S Ciullini Mannurita, D Hagin… - Frontiers in …, 2018 - frontiersin.org
Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX)
Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition …
Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition …
Foxp3 post-translational modifications and Treg suppressive activity
G Deng, X Song, S Fujimoto, CA Piccirillo… - Frontiers in …, 2019 - frontiersin.org
Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing
autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which …
autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which …
Rebalancing immune homeostasis to treat autoimmune diseases
During homeostasis, interactions between tolerogenic dendritic cells (DCs), self-reactive T
cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance …
cells, and T regulatory cells (Tregs) contribute to maintaining mammalian immune tolerance …
Functional reprogramming of regulatory T cells in the absence of Foxp3
Regulatory T cells (Treg cells) deficient in the transcription factor Foxp3 lack suppressor
function and manifest an effector T (Teff) cell–like phenotype. We demonstrate that Foxp3 …
function and manifest an effector T (Teff) cell–like phenotype. We demonstrate that Foxp3 …