Makorin RING finger protein 3 and central precocious puberty
Makorin RING finger protein 3 (MKRN3) is a key inhibitor of the hypothalamic–pituitary–
gonadal axis. Loss-of-function mutations in MKRN3 cause familial and sporadic central …
gonadal axis. Loss-of-function mutations in MKRN3 cause familial and sporadic central …
Bioinformatics Approaches to Explore the Phylogeny and Role of BRCA1 in Breast Cancer
ABSTRACT BRCA1 and BRCA2 are the two major vulnerability genes involved in hereditary
breast cancer. BRCA1 gene programs for a tumor suppressor protein that helps in repairing …
breast cancer. BRCA1 gene programs for a tumor suppressor protein that helps in repairing …
Molecular evolution of the bactericidal/permeability-increasing protein (BPIFA1) regulating the innate immune responses in mammals
Bactericidal/permeability-increasing protein, a primary factor of the innate immune system of
mammals, participates in natural immune protection against invading bacteria. BPIFA1 …
mammals, participates in natural immune protection against invading bacteria. BPIFA1 …
Structural and evolutionary adaptations of Nei‐like DNA glycosylases proteins involved in base excision repair of oxidative DNA damage in vertebrates
Oxidative stress is a type of stress that damages DNA and can occur from both endogenous
and exogenous sources. Damage to DNA caused by oxidative stress can result in base …
and exogenous sources. Damage to DNA caused by oxidative stress can result in base …
Adaptive evolution of peptidoglycan recognition protein family regulates the innate signaling against microbial pathogens in vertebrates
The innate immune system is the first line of defense in vertebrates against microbial
pathogens. This defense system depends on the peptidoglycan pathogen recognition of …
pathogens. This defense system depends on the peptidoglycan pathogen recognition of …
[Retracted] Molecular Evolution of the Activating Transcription Factors Shapes the Adaptive Cellular Responses to Oxidative Stress
Reactive oxygen species (ROS) play an essential part in physiology of individual cell. ROS
can cause damage to various biomolecules, including DNA. The systems that have …
can cause damage to various biomolecules, including DNA. The systems that have …
[HTML][HTML] Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates
Abstract Programmed cell death-1 (PD-1) and its ligands, particularly PD-L1 and PD-L2, are
the most important proteins responsible for signaling T-cell inhibition and arbitrating immune …
the most important proteins responsible for signaling T-cell inhibition and arbitrating immune …
IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate
X Zhu, F Zhang, S Lian, Y Wang, N Hu, X Chen… - Frontiers in …, 2021 - frontiersin.org
Inhibitors of apoptosis proteins (IAPs) are conserved regulators involved in cell cycle, cell
migration, cell death, immunity and inflammation, should be due to the fact that they can …
migration, cell death, immunity and inflammation, should be due to the fact that they can …
Adaptive evolution and functional significance of the PPARGC1A gene across diverse animal species
SM Hosseini, F Ullah, MZ Ahmad… - Ecology and …, 2024 - Wiley Online Library
Codon‐based analyses of the PPARGC1A gene across 38 vertebrate species were
deployed to elucidate patterns of evolutionary change. Employing maximum likelihood …
deployed to elucidate patterns of evolutionary change. Employing maximum likelihood …
Adaptation to host-specific bacterial pathogens drive rapid evolution of novel PhoP/PhoQ regulation pathway modulating the virulence
The presence of the PhoP-PhoQ system is usually different in various bacterial groups,
suggesting that PhoP can control the expression of different genes in species. However, little …
suggesting that PhoP can control the expression of different genes in species. However, little …