Podophyllotoxin and its related aryltetralin cyclolignans belong to a family of important
products that exhibit various biological properties (eg, cytotoxic, insecticidal, antifungal …

Topoisomerases are very important enzymes that regulate DNA topology and are vital for
biological actions like DNA replication, transcription, and repair. The emergence and spread …

Podophyllotoxins and epipodophyllotoxins, possess excellent activity against both drug-
sensitive and drug-resistant even multidrug-resistant cancer cells via inhibition of tubulin …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death attributed
to high frequency of metastasis and multiple drug resistance. We aim to examine the …

A series of new benzimidazole bearing thiazolidinedione derivatives has been designed,
synthesized by using conventional as well as microwave-assisted methods. Microwave …

DNA Topoisomerases (Topos) are ubiquitous nuclear enzymes involved in regulating the
topological state of DNA and, in eukaryotic organisms, Topos can be classified into two …

Topoisomerases (topo-I and topo-II) have occupied a significant role in DNA replication,
transcription, and are a promising set of antitumor targets. In the present approach, a series …

With the rising cancer incidence and mortality globally, there is a prerequisite for effective
design strategies towards the discovery of newer small molecular entities in chemotherapy …

A series of new heterocycles-linked chalcone conjugates has been designed and
synthesized by varying different alkane spacers. These conjugates were tested for their in …

The simple, efficient and recyclable Pd nanoparticles catalyzed one-pot synthesis of new
library of regioselective 4β-aryl pyrazole-epipodophyllotoxin derivatives (6a-o) in …