The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and
to achieve this function it must continually adapt to varying tissue demands. Newly formed …

Reactive hyperemia is a well-established technique for the non-invasive evaluation of the
peripheral microcirculatory function, measured as the magnitude of limb re-perfusion after a …

Myocardial infarction (MI) is one of the leading causes of death worldwide, and inflammation
is central to tissue response and patient outcomes. The 18-kDa translocator protein (TSPO) …

Introduction: Removal of poorly perfused capillaries by pruning contributes to remodeling
the microvasculature to optimize oxygen and nutrient delivery. Blood flow drives this process …

Many ischaemic stroke patients who have a mechanical removal of their clot (thrombectomy)
do not get reperfusion of tissue despite the thrombus being removed. One hypothesis for this …

Thrombectomy, the mechanical removal of a clot, is the most common way to treat ischaemic
stroke with large vessel occlusions. However, perfusion cannot always be restored after …

Vascularized composite allotransplantation can improve quality of life and restore
functionality. However, the complex tissue composition of vascularized composite allografts …

In this review, we provide a summary of the state-of-the-art in the in silico modelling of
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …

The cardiovascular system plays a key role in the transport of nutrients, ensuring a
continuous supply of all cells of the body with the metabolites necessary for life. The blood …

Brain ischaemia causes reduction of cerebral blood flow, which interrupts the transport of
oxygen and glucose to brain tissue. These transport inefficiencies have also been …