Gut barrier disruption and chronic disease

J Martel, SH Chang, YF Ko, TL Hwang… - Trends in Endocrinology …, 2022 - cell.com
The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

Partners in leaky gut syndrome: intestinal dysbiosis and autoimmunity

Y Kinashi, K Hase - Frontiers in immunology, 2021 - frontiersin.org
The intestinal surface is constitutively exposed to diverse antigens, such as food antigens,
food-borne pathogens, and commensal microbes. Intestinal epithelial cells have developed …

Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota

J Ouyang, B Deng, B Zou, Y Li, Q Bu… - Journal of the …, 2023 - ACS Publications
Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as
a protein drug that is easily denatured or degraded in the acidic environment of the stomach …

Implication of intestinal barrier dysfunction in gut dysbiosis and diseases

C Stolfi, C Maresca, G Monteleone, F Laudisi - Biomedicines, 2022 - mdpi.com
The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

How do intestinal probiotics restore the intestinal barrier?

HZ Gou, YL Zhang, LF Ren, ZJ Li, L Zhang - Frontiers in microbiology, 2022 - frontiersin.org
The intestinal barrier is a structure that prevents harmful substances, such as bacteria and
endotoxins, from penetrating the intestinal wall and entering human tissues, organs, and …

Epithelial Toll-like receptors and their role in gut homeostasis and disease

JF Burgueño, MT Abreu - Nature Reviews Gastroenterology & …, 2020 - nature.com
The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

P Praveschotinunt, AM Duraj-Thatte, I Gelfat… - Nature …, 2019 - nature.com
Mucosal healing plays a critical role in combatting the effects of inflammatory bowel disease,
fistulae and ulcers. While most treatments for such diseases focus on systemically delivered …

The role of intestinal mucosal barrier in autoimmune disease: A potential target

J An, Y Liu, Y Wang, R Fan, X Hu, F Zhang… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases are a series of diseases involving multiple tissues and organs,
characterized by the over production of abnormal multiple antibodies. Although most studies …

Probiotics, prebiotics and epithelial tight junctions: a promising approach to modulate intestinal barrier function

EC Rose, J Odle, AT Blikslager, AL Ziegler - International journal of …, 2021 - mdpi.com
Disruptions in the intestinal epithelial barrier can result in devastating consequences and a
multitude of disease syndromes, particularly among preterm neonates. The association …

Cell–cell junctions organize structural and signaling networks

MA Garcia, WJ Nelson… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Cell–cell junctions link cells to each other in tissues, and regulate tissue homeostasis in
critical cell processes that include tissue barrier function, cell proliferation, and migration …