Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond

H Zhao, A Alam, AP Soo, AJT George, D Ma - EBioMedicine, 2018 - thelancet.com
Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific
inflammatory responses that can result in the loss of kidney graft viability. However, the long …

Maximizing kidneys for transplantation using machine perfusion: from the past to the future: A comprehensive systematic review and meta-analysis

AM Hameed, HC Pleass, G Wong, WJ Hawthorne - Medicine, 2016 - journals.lww.com
Background: The two main options for renal allograft preservation are static cold storage
(CS) and machine perfusion (MP). There has been considerably increased interest in MP …

Hypothermic machine perfusion in kidney transplantation

J De Deken, P Kocabayoglu… - Current opinion in organ …, 2016 - journals.lww.com
HMP has proven to be beneficial as a kidney preservation method for all types of renal
grafts, most notably those retrieved from extended criteria donors. Large numbers of …

Machine perfusion of donor organs for transplantation

R Tatum, TJ O'Malley, AS Bodzin… - Artificial …, 2021 - Wiley Online Library
The ever‐widening gap between organ supply and demand has resulted in an organ
shortage crisis that affects patients all over the world. For decades, static cold storage (SCS) …

Shifting paradigms for suppressing fibrosis in kidney transplants: supplementing perfusion solutions with anti-fibrotic drugs

LL van Leeuwen, HGD Leuvenink, P Olinga… - Frontiers in …, 2022 - frontiersin.org
Great efforts have been made toward addressing the demand for donor kidneys. One of the
most promising approaches is to use kidneys from donation after circulatory death donors …

Machine perfusion of extended criteria donor organs: immunological aspects

M Kvietkauskas, B Leber, K Strupas, P Stiegler… - Frontiers in …, 2020 - frontiersin.org
Due to higher vulnerability and immunogenicity of extended criteria donor (ECD) organs
used for organ transplantation (Tx), the discovery of new treatment strategies, involving …

Organ preservation review: history of organ preservation

AM Cameron, JFB Cornejo - Current opinion in organ …, 2015 - journals.lww.com
Organ preservation review: history of organ preservation : Current Opinion in Organ
Transplantation Organ preservation review: history of organ preservation : Current Opinion in …

Marked protection against acute renal and hepatic injury after nitrited myoglobin+ tin protoporphyrin administration

RA Zager - Translational Research, 2015 - Elsevier
The phenomenon known as renal “ischemic preconditioning,” whereby an initial ischemic
insult induces resistance against subsequent kidney damage, has been well established in …

Machine perfusion and long-term kidney transplant recipient outcomes across allograft risk strata

S Sandal, X Luo, AB Massie… - Nephrology Dialysis …, 2018 - academic.oup.com
Background The use of machine perfusion (MP) in kidney transplantation lowers delayed
graft function (DGF) and improves 1-year graft survival in some, but not all, grafts. These …

Immunosuppressive nano-therapeutic micelles downregulate endothelial cell inflammation and immunogenicity

SN Nadig, SK Dixit, N Levey, S Esckilsen, K Miller… - RSC …, 2015 - pubs.rsc.org
In this study, we developed a stable, nontoxic novel micelle nanoparticle to attenuate
responses of endothelial cell (EC) inflammation when subjected to oxidative stress, such as …