The primary function of the skin is to act as a barrier against insults from the environment,
and its unique structure reflects this. The skin is composed of two layers: the epidermal outer …

Melanoma is a highly aggressive cancer with the poorest prognosis, representing the
deadliest form of skin cancer. Activating mutations in BRAF are the most frequent genetic …

The high number of somatic mutations in the melanoma genome associated with cumulative
ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With …

Cutaneous melanoma is the most aggressive type of skin cancer. Although cutaneous
melanoma accounts for a minority of all types of skin cancer, it causes the greatest number …

Incidence of cutaneous malignant melanoma has continued to rise despite public efforts to
promote sun protection behaviors among populations at risk. However, dietary factors may …

Throughout life, organisms are exposed to various exogenous and endogenous factors that
cause DNA damages and somatic mutations provoking genomic instability. At a young age …

Cutaneous malignant melanoma (CMM) and nonmelanoma skin cancers (NMSC),
squamous cell and basal cell carcinomas, have been increasing at exponential rates for as …

Melanoma is an aggressive skin cancer, whose incidence rates have increased over the
past few decades. Risk factors for melanoma are both intrinsic (genetic and familiar …

The incidence of skin cancers, both nonmelanoma and melanoma, is increasing in the
United States. The ultraviolet radiation, mainly from sun, is considered the major cause for …

Reactive oxygen species (ROS) are highly bioactive molecules involved not only in tissue
physiology but also in the development of different human conditions, including premature …