Purpose To review the clinical and laboratory spectrum of RAG gene defects in humans, and
discuss the mechanisms underlying phenotypic heterogeneity, the basis of immune …

Autoimmunity as a continuum in primary immunodeficiency : Current Opinion in Pediatrics
Autoimmunity as a continuum in primary immunodeficiency : Current Opinion in Pediatrics Log …

The recombination-activating genes (RAG) 1 and 2 are indispensable for diversifying the
primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the …

Background Although autoimmunity and hyperinflammation secondary to recombination
activating gene (RAG) deficiency have been associated with delayed diagnosis and even …

Mutations of the recombinase activating genes (RAG) in humans underlie a broad spectrum
of clinical and immunological phenotypes that reflect different degrees of impairment of T …

Background Mutations in recombination-activating gene (RAG) 1 and RAG2 are associated
with a broad range of clinical and immunologic phenotypes in human subjects. Objective …

Abstract Recombination-activating genes (RAG) 1 and RAG2 initiate the molecular
processes that lead to lymphocyte receptor formation through VDJ recombination. Nonsense …

Severe combined immunodeficiency (SCID) is one of the severe inborn errors of the immune
system associated with life-threatening infections. Variations in SCID phenotypes, especially …

Recombination activating genes (RAG) 1 and RAG2 deficiency leads to combined T/B-cell
deficiency with varying clinical presentations. This study aimed to define the …

Corticosteroids, when given in high dosages, have long been recognized as a risk factor for
severe infection with wild-type varicella-zoster virus in both children and adults. The goal of …