Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase
important in B‐lymphocyte development, differentiation, and signaling. Btk is a member of …

A significant fraction of every proteome is occupied by biologically active proteins that do not
form unique three-dimensional structures. These intrinsically disordered proteins (IDPs) and …

Translational motion in solution, either diffusion or fluid flow, is at the heart of chemical and
biochemical reactivity. Nuclear Magnetic Resonance (NMR) provides a powerful non …

The Tec family tyrosine kinases regulate lymphocyte development, activation, and
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …

▪ Abstract The Tec family tyrosine kinases are now recognized as important mediators of
antigen receptor signaling in lymphocytes. Three members of this family, Itk, Rlk, and Tec …

Exquisite control of biological function is achieved via tight regulation of the catalytic and
binding activities of cellular proteins. The mechanistic details of protein regulation vary from …

Interleukin-2 tyrosine kinase (Itk) is a nonreceptor protein tyrosine kinase of the Tec family
that participates in the intracellular signaling events leading to T cell activation. Tec family …

Abstract Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the
immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by …

Abstract Interleukin-2 tyrosine kinase (Itk) is a T cell-specific kinase required for a proper
immune response following T cell receptor engagement. In addition to the kinase domain, Itk …

The Tec kinases are implicated as important components of the antigen receptor signaling
required for proper lymphocyte activation and development. Recent data suggest that these …