Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by
pain, decline in function and reduced exercise tolerance. The most common overuse …

Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

Background Recent investigation of human tissue and cells from positional tendons such as
the rotator cuff has clarified the importance of inflammation in the development and …

Over the past decades, tremendous success in the treatment of psoriasis has been achieved
using biologics, such as neutralizing antibodies against TNF/TNFR, IL-23, and IL-17A/IL …

Tendon injuries are common and debilitating, with non-regenerative healing often resulting
in chronic disease. While there has been considerable progress in identifying the cellular …

Tendon disorders represent the most common musculoskeletal complaint for which patients
seek medical attention; inflammation drives tendon degeneration before tearing and impairs …

Introduction Frozen shoulder is a common, fibro-proliferative disease characterised by the
insidious onset of pain and progressively restricted range of shoulder movement. Despite …

Tendinopathy is a common clinical problem and has a significant disease burden attached,
not only in terms of health care costs, but also for patients directly in terms of time off work …

Tendon injuries heal via a scar-mediated response, and there are no biological approaches
to promote more regenerative healing. Mouse flexor tendons heal through the formation of …

Abstract Knowledge of how the joint functions as an integrated unit in health and disease
requires an understanding of the stromal cells populating the joint mesenchyme, including …