Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …

One of the most important achievements of bacteria is its capability to adapt to the changing
conditions of the environment. The competition for nutrients with other microorganisms …

▪ Abstract Most prokaryotic signal-transduction systems and a few eukaryotic pathways use
phosphotransfer schemes involving two conserved components, a histidine protein kinase …

This review concerns how Escherichia coli detects environmental inorganic orthophosphate
(Pi) to regulate genes of the phosphate (Pho) regulon by the PhoR/PhoB two-component …

Response regulators (RRs) comprise a major family of signaling proteins in prokaryotes. A
modular architecture that consists of a conserved receiver domain and a variable effector …

PhoB is a signal transduction response regulator that activates nearly 40 genes in
phosphate depletion conditions in E. coli and closely related bacteria. The structure of the …

Histidine protein kinases and response regulators form the basis of phosphotransfer signal
transduction pathways. Commonly referred to as two-component systems, these modular …

Background: A variety of bacterial adaptative cellular responses to environmental stimuli are
mediated by two-component signal transduction pathways. In these phosphorelay cascades …

Response regulators are the output component of two-component regulatory systems, the
predominant form of signal transduction systems utilized by prokaryotes. The majority of …

Receiver domains are the dominant molecular switches in bacterial signalling,. Although
several structures of non-phosphorylated receiver domains have been reported,,,,,, a …