[HTML][HTML] The 2023 yearbook of Neurorestoratology

H Huang, JR Bach, HS Sharma, L Chen, P Wu… - Journal of …, 2024 - Elsevier
Remarkable advancements have been made in understanding the pathogenesis of
Alzheimer's disease, Parkinson's disease, and other neurological disease; in our depth of …

Molecular hallmarks of ageing in amyotrophic lateral sclerosis

CJ Jagaraj, S Shadfar, SA Kashani… - Cellular and Molecular …, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing
disorder affecting motor neurons in the brain, brainstem, and spinal cord. Unfortunately …

Identification and in silico screening of natural phloroglucinols as potential PI3Kα inhibitors: A computational approach for drug discovery

F Siddique, O Daoui, M Ayoub, S Elkhattabi… - Open …, 2024 - degruyter.com
Breast cancer is the biggest cause of death among women worldwide. Natural chemicals
from medicinal plants offer promise for cancer therapy. This research screens 29 Dryopteris …

Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis

OM Rifai, FM Waldron, D Sleibi… - Brain …, 2024 - Wiley Online Library
Many genes have been linked to amyotrophic lateral sclerosis (ALS), including never in
mitosis A (NIMA)‐related kinase 1 (NEK1), a serine/threonine kinase that plays a key role in …

NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons

KM Power, KC Nguyen, A Silva, S Singh, DH Hall… - Journal of Cell …, 2024 - rupress.org
Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is
abundant in cilia, and its dysregulation may contribute to ciliopathies and …

Current Strategies and Therapeutic Applications of Mesenchymal Stem Cell-Based Drug Delivery

Y Matsuzaka, R Yashiro - Pharmaceuticals, 2024 - mdpi.com
Mesenchymal stem cells (MSCs) have emerged as a promising approach for drug delivery
strategies because of their unique properties. These strategies include stem cell membrane …

NEK1 haploinsufficiency worsens DNA damage, but not defective ciliogenesis, in C9ORF72 patient-derived iPSC-motoneurons

S Santangelo, S Invernizzi, MN Sorce… - Human Molecular …, 2024 - academic.oup.com
The hexanucleotide G4C2 repeat expansion (HRE) in C9ORF72 gene is the major cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leading to both loss …

Identifying dysregulated regions in amyotrophic lateral sclerosis through chromatin accessibility outliers

MH Celik, J Gagneur, RG Lim, J Wu… - Human Genetics and …, 2024 - cell.com
The high heritability of ALS contrasts with its low molecular diagnosis rate post-genetic
testing, pointing to potential undiscovered genetic factors. To aid the exploration of these …

Association between NEK1 gene polymorphisms and the potential risk of sporadic Parkinson's disease in the Chinese Northern Han population: A case-control study

Q He, Y Zhou, J Jin, Q Tian, H Li, B Hou, A Xie - Neuroscience Letters, 2024 - Elsevier
Objective Parkinson's disease (PD) has been identified as a genetically influenced disease
linked to various genetic loci. Previous studies have suggested that neurodegenerative …

[HTML][HTML] NEKL-4 regulates microtubule stability and mitochondrial health in C. elegans ciliated neurons

KM Power, KC Nguyen, A Silva, S Singh, DH Hall… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is
abundant in cilia, and its dysregulation may contribute to ciliopathies and …