Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …

Cumulative evidence has demonstrated that the ventilatory ratio closely correlates with
mortality in acute respiratory distress syndrome (ARDS), and a primary feature in …

In sepsis, the persistence of uncontrolled inflammatory response of infected host cells
eventually leads to severe lung and organ failure and, ultimately, death. Carbapenem …

Objectives: Extracorporeal carbon dioxide removal (ECCO 2 R) devices are effective in
reducing hypercapnia and mechanical ventilation support but have not been shown to …

Aim Hypercapnia may elicit detrimental haemodynamic effects in critically ill patients. We
aimed to investigate the consequences of targeted mild hypercapnia versus targeted …

The aim of this study was to develop and validate a machine learning-based mortality risk
prediction model for patients with severe community-acquired pneumonia (SCAP) in the …

Background Several extracorporeal carbon dioxide removal (ECCO2R) devices are
currently in use with variable efficacy and safety profiles. PrismaLung+ is an ECCO2R …

BACKGROUND: Lung-protective ventilation (reduced tidal volume and limited plateau
pressure) may lead to CO2 retention. Data about the impact of hypercapnia in patients with …

Objectives Patients with severe acute respiratory distress syndrome (ARDS) often exhibit an
unusually strong respiratory drive, which predisposes them to effort-induced lung injury …

In order to facilitate the normal functioning of many biological processes, particularly
enzymatic proteins, pH is maintained in health between 7.35 and 7.45, in both extra-and …