Cryptococcal meningitis diagnostics and screening in the era of point-of-care laboratory testing

R Rajasingham, RM Wake, T Beyene… - Journal of clinical …, 2019 - Am Soc Microbiol
Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected
persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg) …

The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis

R Rajasingham, NP Govender, A Jordan… - The Lancet infectious …, 2022 - thelancet.com
Background Cryptococcal meningitis is the most common cause of meningitis in adults living
with HIV in sub-Saharan Africa. The estimates of national, regional, and global burden of …

Minimizing fungal disease deaths will allow the UNAIDS target of reducing annual AIDS deaths below 500 000 by 2020 to be realized

DW Denning - … Transactions of the Royal Society B …, 2016 - royalsocietypublishing.org
Deaths from AIDS (1 500 000 in 2013) have been falling more slowly than anticipated with
improved access to antiretroviral therapy. Opportunistic infections account for most AIDS …

CD4 cell count threshold for cryptococcal antigen screening of HIV-infected individuals: a systematic review and meta-analysis

N Ford, Z Shubber, JN Jarvis, T Chiller… - Clinical Infectious …, 2018 - academic.oup.com
Background Current guidelines recommend screening all people living with human
immunodeficiency virus (PLHIV) who have a CD4 count≤ 100 cells/µL for cryptococcal …

High cryptococcal antigen titers in blood are predictive of subclinical cryptococcal meningitis among human immunodeficiency virus-infected patients

RM Wake, E Britz, C Sriruttan, I Rukasha… - Clinical Infectious …, 2018 - academic.oup.com
Background High mortality rates among asymptomatic cryptococcal antigen (CrAg)–positive
patients identified through CrAg screening, despite preemptive fluconazole treatment, may …

[HTML][HTML] The war on cryptococcosis: a review of the antifungal arsenal

A Mourad, JR Perfect - Memórias do Instituto Oswaldo Cruz, 2018 - SciELO Brasil
Cryptococcal meningitis is the most common central nervous system infection in the world
today. It occurs primarily, but not exclusively, in immunocompromised individuals and …

Incidence and risk factors for hypertension among HIV patients in rural Tanzania–A prospective cohort study

E Rodríguez-Arbolí, K Mwamelo, AV Kalinjuma… - PloS one, 2017 - journals.plos.org
Introduction Scarce data are available on the epidemiology of hypertension among HIV
patients in rural sub-Saharan Africa. We explored the prevalence, incidence and risk factors …

Impact of routine cryptococcal antigen screening and targeted preemptive fluconazole therapy in antiretroviral-naive human immunodeficiency virus–infected adults …

E Temfack, JJ Bigna, HN Luma, R Spijker… - Clinical Infectious …, 2019 - academic.oup.com
Cryptococcal antigen (CrAg) screening and targeted preemptive fluconazole in antiretroviral-
naive human immunodeficiency virus–infected adults with CD4 cell counts< 100/μL seems …

Cryptococcal antigenemia in advanced human immunodeficiency virus disease: pathophysiology, epidemiology, and clinical implications

RM Wake, SF Molloy, JN Jarvis… - Clinical Infectious …, 2023 - academic.oup.com
Cryptococcal antigen (CrAg) is detectable in blood prior to the onset of symptomatic
cryptococcal meningitis (CM), a leading cause of death among people with advanced …

Diagnosis and management of central nervous system cryptococcal infections in HIV-infected adults

C Skipper, M Abassi, DR Boulware - Journal of Fungi, 2019 - mdpi.com
Cryptococcal meningitis persists as a significant source of morbidity and mortality in persons
with HIV/AIDS, particularly in sub-Saharan Africa. Despite increasing access to …