Mast cells (MCs) are portions of the innate and adaptive immune system derived from bone
marrow (BM) progenitors that are rich in cytoplasmic granules. MC maturation, phenotype …

Mast cells are immune cells of the myeloid lineage and are present in connective tissues
throughout the body. The activation and degranulation of mast cells significantly modulates …

The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …

Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the
pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to …

Abstract Prostaglandin E 2 (PGE 2) is one of the most typical lipid mediators produced from
arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on …

Immune responses in the CNS are common, despite its perception as a site of immune
privilege. These responses can be mediated by resident microglia and astrocytes, which are …

Hematopoietic cells, including lymphoid and myeloid cells, can develop into phenotypically
distinct'subpopulations' with different functions. However, evidence indicates that some of …

Mast cell activation (MCA) accompanies diverse physiologic and pathologic processes and
is one of the more frequently encountered conditions in medicine. MCA-related symptoms …

Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their
involvement in acquired and innate immunity. Increasing evidence now implicates mast cells …

Centralized pain syndromes are associated with changes within the central nervous system
that amplify peripheral input and/or generate the perception of pain in the absence of a …