Major depression is one of the most prevalent and debilitating personal and public health
conditions worldwide. Less appreciated is that depression's tremendous burdens are not …

Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …

La dépression et l'anxiété sont les deux problèmes de santé mentale les plus courants au
Canada. La pandémie de COVID-19 donnera lieu probablement à une incidence et à une …

Cognitive science has been instrumental in advancing our understanding of the onset,
maintenance, and treatment of depression. Research conducted over the last 50 years …

Major life stressors, especially those involving interpersonal stress and social rejection, are
among the strongest proximal risk factors for depression. In this review, we propose a …

Purpose To review and synthesise prognostic indices that predict subsequent risk,
prescriptive indices that moderate treatment response, and mechanisms that underlie each …

Background Individuals with a history of recurrent depression have a high risk of repeated
depressive relapse or recurrence. Maintenance antidepressants for at least 2 years is the …

Low self-esteem and depression are strongly related, but there is not yet consistent
evidence on the nature of the relation. Whereas the vulnerability model states that low self …

Objectives: Evidence suggests that childhood maltreatment may negatively affect not only
the lifetime risk of depression but also clinically relevant measures of depression, such as …