Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases
Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …
Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …
[HTML][HTML] Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma
Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …
Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial
F Hui, J Tang, PA Williams… - Clinical & …, 2020 - Wiley Online Library
Importance Retinal ganglion cells endure significant metabolic stress in glaucoma but
maintain capacity to recover function. Nicotinamide, a precursor of NAD+, is low in serum of …
maintain capacity to recover function. Nicotinamide, a precursor of NAD+, is low in serum of …
Inducible rodent models of glaucoma
Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …
understand the molecular pathobiology of this disease and to develop better therapies …
Retinal energy metabolism in health and glaucoma
Energy metabolism refers to the processes by which life transfers energy to do cellular work.
The retina's relatively large energy demands make it vulnerable to energy insufficiency. In …
The retina's relatively large energy demands make it vulnerable to energy insufficiency. In …
[HTML][HTML] Electrophysiological assessment of retinal ganglion cell function
V Porciatti - Experimental eye research, 2015 - Elsevier
The function of retinal ganglion cells (RGCs) can be non-invasively assessed in
experimental and genetic models of glaucoma by means of variants of the ERG technique …
experimental and genetic models of glaucoma by means of variants of the ERG technique …
Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies
The retina and brain share similar neurochemistry and neurodevelopmental origins, with the
retina, often viewed as a “window to the brain.” With retinal measures of structure and …
retina, often viewed as a “window to the brain.” With retinal measures of structure and …
[HTML][HTML] Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas
M Vidal-Sanz, M Salinas-Navarro… - Progress in retinal and …, 2012 - Elsevier
Glaucoma, the second most common cause of blindness, is characterized by a progressive
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …
loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field …
The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells
Sustained increase in intraocular pressure represents a major risk factor for eye disease, yet
the cellular mechanisms of pressure transduction in the posterior eye are essentially …
the cellular mechanisms of pressure transduction in the posterior eye are essentially …