The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron loss, with additional pathophysiological involvement of non …

A brain organoid is a self-organizing three-dimensional tissue derived from human
embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and …

The routine clinical integration of individualized objective markers of disease activity in those
diagnosed with the neurodegenerative disorder amyotrophic lateral sclerosis is a key …

Objective To evaluate the classifier performance, clinical and biochemical correlations of
cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1) …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is an incurable
neurodegenerative condition, characterized by the loss of upper and lower motor neurons. It …

Advances in neuroimaging, complementing histopathological insights, have established a
multi-system involvement of cerebral networks beyond the traditional neuromuscular …

Background Premorbid body mass index, physical activity, diabetes and cardiovascular
disease have been associated with an altered risk of developing amyotrophic lateral …

The amyotrophic lateral sclerosis (ALS) functional rating scale‐revised (ALSFRS‐R) has
become the most widely utilized measure of disease severity in patients with ALS, with …