Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it
secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As …

Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a
commonly affected organ. We found that activation of lung-resident group 2 innate lymphoid …

Immunotherapy shifted the paradigm of cancer treatment. The clinical approval of immune
checkpoint blockade and adoptive cell transfer led to considerable success in several tumor …

The signaling pathways downstream of the insulin receptor (InsR) are some of the most
evolutionarily conserved pathways that regulate organism longevity and metabolism. InsR …

Lung innate immunity is the first line of defence against inhaled allergens, pathogens and
environmental pollutants. Cellular metabolism plays a key role in innate immunity. Catabolic …

Granulocytes (neutrophils, eosinophils, and basophils) are the most abundant circulating
cells in the innate immune system. Circulating granulocytes, primarily neutrophils, can cross …

Allergic asthma and influenza are common respiratory diseases with a high probability of co-
occurrence. During the 2009 influenza pandemic, hospitalized patients with influenza …

Eosinophils are implicated in the pathophysiology of a spectrum of eosinophil-associated
diseases, including gastrointestinal eosinophilic diseases (EGIDs). Biologics that target the …

Immune cell activation leads to the acquisition of new functions, such as proliferation,
chemotaxis, and cytokine production. These functional changes require continuous …