One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability
after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords …

Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because
these act in parallel, no single intervention has been sufficient to enable full regeneration of …

The failure of axons to regenerate in the damaged mammalian CNS is the main impediment
to functional recovery. There are many molecules and structures in the environment of the …

A spinal cord injury is a form of physical harm imposed on the spinal cord that causes
disability and, in many cases, leads to permanent mammalian paralysis, which causes a …

Mammalian neurons lose the ability to regenerate their central nervous system axons as
they mature during embryonic or early postnatal development. Neuronal maturation requires …

Following damage to a peripheral nerve, injury signaling pathways converge in the cell body
to generate transcriptional changes that support axon regeneration. Here, we demonstrate …

Axons in the adult mammalian nervous system can extend over formidable distances, up to
one meter or more in humans. During development, axonal and dendritic growth requires …

Axons are a unique cellular structure that allows for the communication between neurons.
Axon damage compromises neuronal communications and often leads to functional deficits …