The microvasculature plays a central role in the pathophysiology of hemorrhagic shock and
is also involved in arguably all therapeutic attempts to reverse or minimize the adverse …

Traumatic brain injury (TBI) and severe blood loss (SBL) frequently co-occur in human
trauma, resulting in high levels of mortality and morbidity. Importantly, each of the individual …

Repeated mild traumatic brain injury (rmTBI) caused by playing collision sports or by
exposure to blasts during military operations can lead to late onset, chronic diseases such …

Traumatic brain injury and hemorrhagic shock (TBI+ HS) elicit a complex inflammatory
response that contributes to secondary brain injury. There is currently no proven …

Objective To investigate the effects of Shenfu Injection (参附注射液, SFI) on endothelial
damage in a porcine model of hemorrhagic shock (HS). Methods After being bled to a mean …

Background We have shown that early administration of fresh frozen plasma (FFP) reduces
the size of brain lesions 6 hours after injury in a large animal model of traumatic brain injury …

Background Traumatic brain injury poses an enormous clinical challenge. Rats are the
animals most widely used in pre-clinical experiments. Biomechanical simulations of these …

Methods: Swine underwent TBI+ HS, kept in shock for 2 h, and resuscitated with FFP or
FFP+ VPA (n= 5/group). After 6 h of observation, brain RNA was isolated and gene …

BACKGROUND Hypernatremia is a common problem affecting critically ill patients, whether
due to underlying pathology or the subsequent result of hypertonic fluid resuscitation …

Traumatic brain injury (TBI) is a leading cause of death in young adults, and effective
treatment strategies have the potential to save many lives. TBI results in coagulopathy …