While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

The adoption of the concept that asthma is primarily a disease most frequently associated
with elaboration of T‐helper 2 (Th2)‐type inflammation has led to the widely held concept …

PD-L1 expression in primary clear-cell renal cell carcinoma (ccRCC) increases the
likelihood of response to anti–PD-1 inhibition, but fails to identify all responders. We …

The small airways are defined as those less than 2 mm in diameter. They are a major site of
pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) …

This study was designed to examine the inflammatory process in the central and peripheral
airways of surgically resected lungs from asthmatic and nonasthmatic subjects. Lung …

To quantify the number of goblet cells and inflammatory cells in the epithelium of peripheral
airways in smokers with both symptoms of chronic bronchitis and chronic airflow limitation …

Asthma and COPD have a high personal, societal, and economic impact. Both diseases are
characterized by airway obstruction and an inflammatory process. The inflammatory process …

Asthma is characterized by chronic lower airway inflammation that results in airway
remodeling, which can lead to a permanent decrease in lung function. The pathophysiology …

Small airway disease is thought to contribute significantly to functional impairment caused
by asthma. Functional evidence of airway-parenchyma uncoupling in asthma, such as loss …

Structural changes reported in the airways of asthmatics include epithelial fragility, goblet
cell hyperplasia, enlarged submucosal mucus glands, angiogenesis, increased matrix …